以小鼠模式研究TH1與TH2型腎絲球腎炎之致病機轉與治療
Date Issued
2001
Date
2001
Author(s)
DOI
892313B002199
Abstract
Renal injury in glomerulonephritis (GN) is characterized by injurious immune
responses to self or foreign antigen. These create often an unrecovered renal
injury in human. Therefore, many GN-prone and lipopolysaccharde
(LPS)-induced mice model were established for the research of GN. The
different mice model showed also the different effect of Th cell subsets. The
induction of a chronic state of polyclonal activation of lymphocytes by LPS
triggers a lupus-like mesangial proliferative GN. According the reported data,
however, it normally took at least 2 or more weeks to induce the glomerular
disease, which showed predominantly mesangial and/or endothelial cell
proliferation. In our data, we found that consecutive 7 daily i.v. low doses of LPS
induced acute proliferative and exudative glomerular lesions in ICR mice. These
mice also showed intermittent hematuria and slight proteinuria. This study
investigated the pathogenesis of acute glomerular damage and evaluated the
effect of IL-4 and IL-12 expressing plasmid on this type of glomerular injury in
ICR mice. The results of preventive and post treatment showed potential
therapeutic effect, But we still need further study to confirm the conclusion.
Subjects
Glomerulonephr itis
lipopolysaccharde
inter leukin-4
inter leukin-12
ICR mice
SDGs
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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