以小鼠模式研究TH1與TH2型腎絲球腎炎之致病機轉與治療

Abstract

Renal injury in glomerulonephritis (GN) is characterized by injurious immune responses to self or foreign antigen. These create often an unrecovered renal injury in human. Therefore, many GN-prone and lipopolysaccharde (LPS)-induced mice model were established for the research of GN. The different mice model showed also the different effect of Th cell subsets. The induction of a chronic state of polyclonal activation of lymphocytes by LPS triggers a lupus-like mesangial proliferative GN. According the reported data, however, it normally took at least 2 or more weeks to induce the glomerular disease, which showed predominantly mesangial and/or endothelial cell proliferation. In our data, we found that consecutive 7 daily i.v. low doses of LPS induced acute proliferative and exudative glomerular lesions in ICR mice. These mice also showed intermittent hematuria and slight proteinuria. This study investigated the pathogenesis of acute glomerular damage and evaluated the effect of IL-4 and IL-12 expressing plasmid on this type of glomerular injury in ICR mice. The results of preventive and post treatment showed potential therapeutic effect, But we still need further study to confirm the conclusion.