https://scholars.lib.ntu.edu.tw/handle/123456789/177151
標題: | Comparing a piezoelectric quartz crystal with an optical coagulometer in monitoring high-dose heparin therapy by determining whole blood activated partial thromboplastin time and activated clotting time | 作者: | Lin, Tsun-Mei Cheng, Tzong-Jih Wu, Tsui-Hsun Chang, Hsien-Chang |
關鍵字: | Activated clotting time; Activated partial thromboplastin time; Coagulometer; Heparin; Piezoelectric quartz crystal | 公開日期: | 2005 | 起(迄)頁: | 270-277 | 來源出版物: | Sensors and Actuators B Chemical | 摘要: | The activated partial thromboplastin time (aPTT) and the activated clotting time (ACT) were examined ex-vivo and in vitro, respectively, using a coagulometer based on a piezoelectric quartz crystal (PQC) sensor. A magno-mechanical and an optical coagulometer were employed to determine ACT and aPTT values in high-dose heparin therapy to evaluate the performance of the coagulometers. The correlations between aPTTs with a PQC coagulometer and ACTs with a magno-mechanical coagulometer were sufficient (>0.91) for a high-dose range (0-4 units/ml) of heparin in blood plasma and whole blood. Ex-vivo investigations of high-dose heparin therapy were also conducted to evaluate the analytical performance (sensitivity and specificity) of a PQC coagulometer, based on the receiver-operating characteristic. No false-positive or false-negative result was obtained in distinguishing the coagulation effect of 10,000 units of heparin administrated to subjects, using a suitable cut-off value (101 s) for whole blood aPTTs (WBaPTT) measured using a PQC coagulometer. The WBaPTT outperformed PLaPTT with a PQC coagulometer in terms of both safety (sensitivity = 100%) and accuracy (specificity = 97) (sensitivity = 100%, specificity = 87% in PLaPTT) and OCaPTT (sensitivity = 100%, specificity = 87%) with an optical coagulometer. ? 2005 Elsevier B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/184914 | DOI: | 10.1016/j.snb.2004.12.058 | SDG/關鍵字: | Blood; Cells; Crystals; Health risks; Monitoring; Patient treatment; Plasmas; Quartz; Activated clotting time; Activated partial thromboplastin time; Coagulometers; Heparin; Piezoelectric quartz crystals; Piezoelectric devices |
顯示於: | 生物機電工程學系 |
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