https://scholars.lib.ntu.edu.tw/handle/123456789/183989
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Yang, Hsin-Ling | en |
dc.contributor.author | Kuo, Yueh-Hsiung | en |
dc.contributor.author | Tsai, Ching-Tsan | en |
dc.contributor.author | Huang, Yi-Ting | en |
dc.contributor.author | Chen, Ssu-Ching | en |
dc.contributor.author | Chang, Hsueh-Wei | en |
dc.contributor.author | Lin, Elong | en |
dc.contributor.author | Lin, Wen-Hsin | en |
dc.contributor.author | Hseu, You-Cheng | en |
dc.creator | Yang, Hsin-Ling;Kuo, Yueh-Hsiung;Tsai, Ching-Tsan;Huang, Yi-Ting;Chen, Ssu-Ching;Chang, Hsueh-Wei;Lin, Elong;Lin, Wen-Hsin;Hseu, You-Cheng | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-05-12T10:36:57Z | - |
dc.date.accessioned | 2018-07-10T09:59:04Z | - |
dc.date.available | 2012-05-12T10:36:57Z | - |
dc.date.available | 2018-07-10T09:59:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/239255 | - |
dc.description.abstract | The fermented culture broth of Antrodia camphorata (A. camphorata) has been shown to promote cell cycle arrest and apoptosis of human estrogen-nonresponsive MDA-MB-231 cells. Herein, we demonstrate that non-cytotoxic concentrations (20-80. μg/mL) of A. camphorata markedly inhibited the invasion/migration of highly metastatic MDA-MB-231 cells as shown by an in vitro transwell and a wound-healing repair assay. The results of a gelatin zymography assay showed that A. camphorata suppressed the activity of matrix metalloproteinase (MMP)-9 and urokinase plasminogen activator (uPA). Western blot results demonstrated that treatment with A. camphorata decreased the expression of MMP-9, MMP-2, uPA, uPA receptor (uPAR) and vascular endothelial growth factor (VEGF); while the expression of the endogenous inhibitors of these proteins, i.e., tissue inhibitors of MMP (TIMP-1 and TIMP-2), and plasminogen activator inhibitor (PAI)-1, increased. Further investigation revealed that A. camphorata suppressed the phosphorylation of ERK1/2, p38, and JNK1/2. A. camphorata treatment also led to a dose-dependent inhibition on NF-κB binding and activation. This is the first report confirming the anti-metastatic activity of this potentially beneficial mushroom against human breast cancer. ? 2010 Elsevier Ltd. | - |
dc.language.iso | en_US | - |
dc.relation | FOOD AND CHEMICAL TOXICOLOGY, 49(1), 290-298 | en |
dc.relation.ispartof | Food and Chemical Toxicology | en_US |
dc.subject | Antrodia camphorata; Breast cancer; Chinese herb; Matrix metalloproteinase; Metastasis; Nuclear factor κB | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gelatinase A; gelatinase B; immunoglobulin enhancer binding protein; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase p38; plasminogen activator inhibitor; stress activated protein kinase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 2; urokinase; urokinase receptor; vasculotropin; Antrodia camphorata; apoptosis; article; assay; breast cancer; cancer cell; cell cycle arrest; cell invasion; cell migration; concentration response; controlled study; enzyme repression; fungus culture; human; human cell; in vitro study; metastasis inhibition; mushroom; protein expression; signal transduction; Western blotting; zymography; Antrodia; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Humans; MAP Kinase Signaling System; Matrix Metalloproteinases; Neoplasm Metastasis; Phosphorylation; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Basidiomycota; Taiwanofungus camphoratus | - |
dc.title | Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.fct.2010.10.031 | en |
dc.relation.pages | 290-298 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/239255/-1/241.pdf | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
item.openairetype | journal article | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
顯示於: | 化學系 |
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