Interim Analysis and Data Monitoring in Clinical Trials
Date Issued
2006-08-24
Date
2006-08-24
Author(s)
DOI
20060927123050835275
Abstract
Sample mean of N observations
The variance of sample mean =σ2/N.
The information about the population mean provided by the sample mean is N/σ2.
If σ2=1, the information about the population mean provided by the sample of N observation is simply the sample size N.
This is the definition of statistical information which can be also interpreted as the clinical information
The planned sample size is the minimum clinical and statistical information required to achieve the desired power for detecting a minimum clinically meaningful difference at a pre-determined risk of typeⅠerror.
Publisher
臺北市:國立臺灣大學農藝學系
Type
learning object
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