Chapter 15 Gene Mapping in Eukaryotes

Abstract

1. Genes on non-homologous chromosomes assort independently, but genes on the same chromosome (syntenic genes) may instead be inherited together (linked), and belong to a linkage group. 2. Classical genetics analyzes the frequency of allele recombination in progeny of genetic crosses. a. New associations of parental alleles are recombinants, produced by genetic recombination. b. Testcrosses determine which genes are linked, and a linkage map (genetic map) is constructed for each chromosome. c. Genetic maps are useful in recombinant DNA research and experiments dealing with genes and their flanking sequences. 3. Current high-resolution maps include both gene markers from testcrosses, and DNA markers composed of genomic regions that differ detectably between individuals.