https://scholars.lib.ntu.edu.tw/handle/123456789/186668
Title: | Peroxisome Proliferation, Adipocyte Determination and Differentiation of C3h10t1/2 Fibroblast Cells Induced by Humic Acid: Induction of Ppar in Diverse Cells | Authors: | Lee, Yashang Huang, Tien-Shang Yang, Mei-Ling Huang, Lan-Ru Chen, Ching-Hsein Lu, Fung-Jou 陳健弘 |
Issue Date: | 1999 | Journal Volume: | v.179 | Journal Issue: | n.2 | Start page/Pages: | 218-225 | Source: | JOURNAL OF CELLULAR PHYSIOLOGY | Abstract: | Humic acid, a high-molecular-weight polyphenolic compound, exists abundantly in soil, natural water, and various terrestrial and aquatic environments. Humic acid causes peroxisome proliferation in mouse liver and induces the expression of peroxisome proliferator activated receptor ( PPAR) in BNL CL.2 cells. Both cytotoxicity and flow cytometry show that humic acid inhibits the growth of C3H10T 1/2 cells at G(1) phase. C3H10T1/ 2 fibroblast cells express PPAR gamma and the adipocyte P2 (aP2) genes which convert into adipocytes after being treated with humic acid. Our findings may provide a unique model for studying the molecular control of determination and differentiation of mesodermal cell lineages, (C) 1999 Wiley-Liss, Inc. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88549 |
Appears in Collections: | 醫學系 |
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