https://scholars.lib.ntu.edu.tw/handle/123456789/186692
標題: | Tth Hypothalamus-Pituitary-Ovary and Hypothalamus-Pituitary-Thyroid Axes in Spinal Cord-Injured Women 女性脊髓損傷患者之下視丘─腦垂體─卵巢軸與 下視丘─腦垂體─甲狀腺軸 |
作者: | HUANG, TIEN-SHANG WANG, YEN-HO LAI, JIN-SHIN CHANG, CHING-CHUNG LIEN, I-NAN 黃天祥 王顏和 賴金鑫 張慶忠 連倚南 |
公開日期: | 1996 | 卷: | v.45 | 期: | n.6 | 起(迄)頁: | 718-722 | 來源出版物: | Metabolism | 摘要: | Sixteen women with spinal cord injury (SCI) underwent studies of hypothalamus-pituitary-ovary(HPO) and hypothalamus- pituitary-thyroid(HPT) axes with luteinizing hormone (LH) releasing hormone (LHRH) and thyrotropin (TSH) releasing hormone(TRH) stimulation tests during the early follicular phase. The mean interval from injury to participation in this study was 7.5 years (range, 1.5 to 13. 1). All subjects were menstruating regularly. Five (35.7%) SCI subjects who were menstruating before injury had postinjury amenorrhea for 1 to 12 months, and the other nine (64.3%) SCI subjects had no interruption of menstruation after injury . Two SCI subjects whose injury occurred in preadolescence proceeded to menarche without any delay. The amount of menstrual flow was noted to be reduced in nine (64 .3%) SCI subjects. Two and three SCI subjects had elevated follicle-stimulating hormone (FSH) and prolactin (PRL) levels, respectively. LH responses to LHRH were significantly higher in the SCI group (P < .001). Ten (62.6% ) SCI subjects had enhanced LH responses to LHRH. The mean TSH, PRL, and FSH responses to TRH and LHRH of the SCI group were not significantly different from those of age-matched controls. However, five(31.2%), four (25.0%), and five (31.2 %) SCI subjects had enhanced TSH, PRL, and FSH responses to TRH and LHRH, respectively. Six ( 37.5%) SCI subjects had a delayed FSH response to LHRH. In total, 13 (81.2 %) SCI subjects had at least one axis abnormality. These findings are consistent with the hypothesis that changes of central neurotransmitters may occur after SCI. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/99573 |
顯示於: | 醫學系 |
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