https://scholars.lib.ntu.edu.tw/handle/123456789/187303
標題: | The I27l Amino Acid Polymorphism of the Hepatic Nuclear Factor-1α Is a Risk Factor for Both Insulin Resistance and the Common Form of Type 2 Diabetes | 作者: | CHIU, KEN-C CHUANG, LEE-MING |
公開日期: | 2000 | 卷: | v.85 | 起(迄)頁: | 2178-2183 | 來源出版物: | JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM | 摘要: | Although mutations of the hepatic nuclear factor-1 (HNF-1) have been found in patients with maturity-onset diabetes of the young, HNF-1 played a very little role on the common form of type 2 diabetes. To investigate the role of I 27L, a common amino acid polymorphism, of HNF-1 on glucose metabolism, insulin sensitivity and -cell function were assessed in a group of healthy, glucose tolerant and normotensive subject using a hyperglycemic clamp. The LL subjects had a lower insulin sensitivity index (ISI, 5.178M/m2/min/pM) than the II or IL subjects (7. 401 M/m2/min/ pM, p=0.018 by Mann-Whitney test). The LL subjects had a higher first phase insulin response (2,267 pM) than the II or IL subjects (1,682 pM, p=0.026 by Mann-Whitney test). After adjusting for covariates, the I27L polymorphism was found to be an independent determinant for ISI ( p=0.004). However, it had no impact on -cell function after adjusting for ISI. By pooling five published data on the I27 L polymorphism, we also found that the L allele was a risk factor for diabetes with a odds ratio of 1.35 (1.11-1.60, 95 % CI). We concluded that the I27L polymorphism is a risk factor for both insulin resistance and type 2 diabetes. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88241 |
顯示於: | 醫學系 |
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