|Title:||Beta Cell Function Declines with Age in Glucose Tolerant Caucasians||Authors:||Chiu, Ken C.
Lee, Nancy P.
|Issue Date:||2000||Source:||CLINICAL ENDOCRINOLOGY||Journal Volume:||v.53||Start page/Pages:||569-575||Abstract:||
ABSTRACT OBJECTIVE: As type 2 diabetes results from an imbalance between insulin sensitivity and beta cell function , either or both may worsen with age. However, existing data are controversial on the effect of aging on both insulin sensitivity and beta cell function. RESEARCH DESIGN AND METHODS: A cross-sectional study was designed to examine the impact of age on insulin sensitivity and beta cell function . We enrolled 149 healthy, glucose tolerant and normotensive Caucasians (age 35 ± 1 years old, body mass index 26.07 ±0.44 kg/m2, waist-hip ratio 0.842 ± 0.009 cm/cm, mean ±standard error). Their beta cell function (%B) and insulin sensitivity ( %S) were estimated using the Homeostasis Model Assessment. RESULTS: Simple regression analysis revealed that %B declined with age (p=0.008) while no relation was found between %S and age (p=0.769). A stepwise regression analysis revealed that body mass index and diastolic blood pressure explained 14.7% of variation in %S, while age, waist-hip ratio, gender, and systolic blood pressure had no influence on %S. Age was an independent determinant for %B and it, along with body mass index and diastolic blood pressure, accounted for 21.7% of variation in %B. CONCLUSIONS: In the present study, we showed that beta cell function declined with age at a rate of about 1% per year. In contrast, insulin sensitivity was not affected by aging. Our observations suggest that the age-related decline in glucose tolerance is primarily related to the loss of beta- cell function.
|Appears in Collections:||醫學系|
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