|Title:||Surrogate Estimates of Insulin Sensitivity in Subjects with Hypertension||Authors:||HWU, CHII-MIN
HUNG, YI- REN
CHEN, YII-DER I.
|Keywords:||insulin sensitivity;steady-state plasma glucose;surrogate estimates;HOMEOSTASIS MODEL ASSESSMENT;BLOOD-PRESSURE;CHECK INDEX||Issue Date:||2007||Journal Volume:||v.21||Journal Issue:||n.3||Start page/Pages:||246-252||Source:||JOURNAL OF HUMAN HYPERTENSION||Abstract:||
The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady- state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR ) and quantitative insulin sensitivity check index ( QUICKI)) , and indices from fasting and/or 2 h samples (ISI0,120 and ISITX ) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation ( Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX ( all P<0. 0001). Log ( ISI0,120) seemed to have a better correlation with SSPG (r = -0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log ( ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log ( ISI0,120 ) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI 0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension.
|Appears in Collections:||醫學系|
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