https://scholars.lib.ntu.edu.tw/handle/123456789/187681
標題: | Molecular Epidemiology of Carbapenem-Resistant Pseudomonas Aeruginosa Carrying Metallo-H-Lactamase Genes in Taiwan | 作者: | HUANG, YU-TSUNG CHANG, SHAN-CHWEN YANG, TSAI-LIN YANG, ALMIRA J. WANG, JANN-TAY |
關鍵字: | Carbapenem resistance;Pseudomonas aeruginosa;Metallo-h-lac;Colistin | 公開日期: | 2007 | 卷: | v.59 | 期: | n.2 | 起(迄)頁: | 211-216 | 來源出版物: | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 摘要: | Seventy-two isolates of carbapenem-resistant Pseudomonas aeruginosa (CRPA ) collected through the Taiwan Surveillance of Antimicrobial Resistance ( TSAR) program in 2000 and 2002 were studied for carriage of metallo-h- lactamase (MBL), integrase genes, and integrons. Epidemiologic relatedness was determined using pulsed-field gel electrophoresis. The prevalence of the MBL genes among CRPA was 36.0% (9 of 25) in TSAR II and 17.0% (8/47) in TSAR III, with prevalence in surveyed hospitals being 19.1% (4/ 21, TSAR II) and 23.1% (6 of 26, TSAR III). The blaVIM-3 was detected in 15 of the 17 MBL-positive isolates; the remainder possessed blaVIM-2. The blaIMP was not evident. Class 1 integron was detected in all MBL-positive isolates; amplicon DNA sequences containing the blaVIM-3 regions were all identical. All MBL- positive isolates remained susceptible to colistin. Molecular typing revealed a predominant strain that comprised 14 of the isolates among the various surveyed hospitals. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88430 |
顯示於: | 醫學系 |
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