|Title:||No Association between Gly971arg Variant of the Insulin Receptor Substrate-1 Gene and Non-Insulin-Dependent Diabetes Mellitus in Taiwanese Population||Authors:||CHUANG, LEE-MING
LIN, BONIFACE JUISIANG
|Issue Date:||1996||Journal Volume:||v.19||Journal Issue:||n.5||Start page/Pages:||446-449||Source:||DIABETES CARE||Abstract:||
OBJECTIVE- To study the role of the Gly971Arg variant of IRS-1 gene in the development of NIDDM in the Chinese population living in Taiwan. RESEAR~H DESIGN AND METHODS- Eighty-two unrelated normal controls, 89 subjects with NIDDM , and 23 multiplex families were recruited in Taiwan. All of them were Han Chinese. Pedigree members without a history of diabetes were studied by the standard 75 9 oral glucose tolerance. Detection of the Gly971Arg variant of the IRS-1 gene was performed by polymerase chain reaction and the restriction fragment length polymorphism analysis. RESULTS- The frequency of Gly971Arg variant of the IRS-1 gene in the normal population was 1.2% which was lower than those reported in the Caucasian populations. The prevalence of the Gly971Arg variant was not significantly increased in both non-selected NIDDM population (1.1 %) and the probands of the multiplex families (4.3%). More importantly, the Gly 971 Arg variant of the IRS-1 gene did not cosegregate with BMI and NIDDM in these families. CONCLUSIONS- The Gly971Arg variant of the IRS-1 gene is an infrequent normal allele among Taiwanese. This variant is neither associated nor cosegregated with NIDDM in the Taiwanese population and families. Gly971Arg of IRS-1 gene does not play an important role in the development of NIDDM in this population.
|Appears in Collections:||醫學系|
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