|Title:||Thyrotropin-Releasing Hormone, Chlorpromazine and L-Dopa or Bromocriptin Tests in Cushing’s Syndrome Due to Adrenal Hyperplasia and Adrenal Adenoma
Tsh, Cpz及i-Dopa或cb 154試驗在腎上腺增生過盛及腎上腺腫瘤引起的庫欣氏症候群
|Keywords:||TRH;l-dopa;CB 154 tests;adrenal hyperplasia and adenoma||Issue Date:||1981||Journal Volume:||v.80||Journal Issue:||n.1||Start page/Pages:||7-18||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
TRH and CPZ stimulation test and l-dopa or CB 154 suppression test were performed in 5 cases of Cushing's syndrome with adrenocortical hyperplasia before and after adrenal surgery. The TSH responses to TRH in both groups were suppressed before operation and recovered after operation. The PRL response to TRH in adenoma group was quite normal, but it was suppressed in hyperplasia group before operation. After operation, the PRL response to TRH lowered in adenoma group and rose to the same level as adenoma group in hyperplasia group. The PRL response to CPZ was absent before operation and positive after operation in adenoma group. It was positive in hyperplasia group before and after operation, though the degree or response was slightly exaggerated after operation. The PRL levels were suppressed by l-dopa before operation and CB 154 before and after operation in adenoma group. In hyperplasia group, the PRL response was blunted after l- dopa suppressed before and after operation but recovered after operation. CB 154 suppressed PRL levels before and after operation. From these results, it is suggested that the pathogenesis of Cushing's disease is in the pituitary.
|Appears in Collections:||醫學系|
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