|Title:||TSH receptor in thyroid neoplasms
|Keywords:||thyrotropin receptor;thyroid neoplasm||Issue Date:||1985||Journal Volume:||v.84||Journal Issue:||n.4||Start page/Pages:||441-447||Source:||Journal of the Formosan Medical Association||Abstract:||
Radioreceptor assay technique was used to study the TSH receptor in thyroid neoplasms. The results showed normal thyroid tissues had high and low affinity receptor. The affinity constants were 3.8 +/- 1.93 X 108M-1( mean +/- SD) for high affinity receptor, and 2.45 +/- 2.76 X 107M-1 for low affinity receptor. The capacities were 1.09 +/- 0.58 pmol/mg for the former and 9.48 +/- 4.60 pmol/mg for the latter. Follicular and papillary carcinoma had both kinds of TSH receptors. Only low affinity receptor with less capacity was present in medullary carcinoma. In anaplastic carcinoma , the TSH receptor was either absent, or when present, it was of low affinity receptor. Only low affinity receptor was noted in squamous cell carcinoma. No TSH receptor was present in desmoid. In conclusion, the presence of high affinity TSH receptor is highly related to follicular cells and to the degree of their differentiation. Low affinity TSH receptor is not specific for follicular cells.
|Appears in Collections:||醫學系|
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