https://scholars.lib.ntu.edu.tw/handle/123456789/187935
標題: | 大腸直腸癌腺腫-腺癌自然病史之探討 | 其他標題: | The natural history of adenoma – carcinoma of colorectal cancer | 作者: | 翁昭旼 | 關鍵字: | 大腸直腸癌;腺癌;腺腫;自然病史;Colorectal cancer;Adenoma;Polyp;Nature history | 公開日期: | 1999 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | 本研究目的是利用配對病例對照研究 法(Matched case-control study)配合隨機模式來:1. 估計是否腺腫發生年齡分佈是較腺癌為前;2. 估計由正常至腺腫、由腺腫至腺癌之轉移率;3. 利用2 來估計腺腫轉變為腺癌之5 年及10 年之累積發生率;研究結果發現在正常、腺腫及腺癌三組 之平均年齡及標準差分別為51.71 歲 (16.41)、58.55 歲(13.67)及64.09 歲(12.16)。 腺腫的年發生率及由腺腫轉移到侵入性腺 癌之惡性轉移率分別為1.21%(95%信賴區 間為1.17%~1.24%)及0.64%(95%信賴區間 為0.57%~0.72%)。若按年齡加以分層,則 腺腫的年發生率及惡性轉移率均呈U 字 型。在追蹤一年、五年、十年及十五年之 後,由腺腫到侵入性腺癌惡性轉移的累積 危險性分別為0.48%、2.37%、4.69%及6.95%。利用此結果推論10 年大腸癌篩檢,對 於腺腫轉移至侵入性腺癌,能降低85%的轉移率。 A matched case-control study in conjunction with stochastic models is performed. 1.to examine whether diagnosis distribution of adenoma age diagnosis for is ahead of colorectal cancer. 2.to estimate transition rates from normal, adenoma to colorectal cancer. 3.to calculate 5- and 10-year cumulative incidence rate of malignant transformation. Our results find that mean (S.D) age of normal, adenoma and colorectal cancer were 51.71 (16.64) years, 58.55 (13.67) years and 64.09 (12.16) years, respectively. Annual incidence rate and annual rate of malignamt transformation aree estimated as 1.21% (95% CI: 1.17~1.24) and 0.64%(95% CI: 0.57%~ 0.72%), respectively. The estimation of annual incidence of adenoma and annual rate of malignant transformation stratified by age show a U-shape figure. The cumulative risk of malignant transformation from adenoma to invasive adenocarcinoma by annual, five-yearly and ten-yearly are 0.48%, 2.37% and 6.95% respectively. The results imply that ten-yearly colonscopy screening for adenoma can reduce approximately 85% invasive adenocarcinoma. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/23415 | 其他識別: | 882314B002196 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
檔案 | 描述 | 大小 | 格式 | |
---|---|---|---|---|
882314B002196.pdf | 26.21 kB | Adobe PDF | 檢視/開啟 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。