|Title:||Clinical significance of cytomorphology and thyroid antibodies in autoimmune thyroiditis||Authors:||CHANG, TIEN-CHUN
|Keywords:||needle aspiration cytology;thyroid antibody;autoimmune thyroiditis||Issue Date:||1988||Journal Volume:||v.87||Journal Issue:||n.5||Start page/Pages:||538-543||Source:||Journal of the Formosan Medical Association||Abstract:||
The purposes of this study were to understand if there is any difference in the cytomorphology and thyroid antibodies in different thyroid functional state in autoimmune thyroiditis, and to elucidate if the cytomorphology or thyroid antibodies of autoimmune thyroiditis could be used as parameters for the prediction of the response of goiter size to thyroid hormone treatment. The thyroid functional states of 106 cases were determined by the radioimmunoassay of hormones. The thyroid antibodies were determined by hemagglutination technique. The smears of fin needle aspiration were reviewed. The decrease of goiter size after treatment by thyroxine for 6 months in 101 cases in euthyroid or hypothyroid state was evaluated. Then the cytomorphology and thyroid antibodies were correlated with thyroid functional states and response to thyroxine treatment. The result showed that the Hürthle cell were more frequently found in hypothyroid state (41.7%) than in either euthyroid state (15.6%) (p<0.005) or hyperthyroid state (0% ) (p<0.05). The incidence of the presence of follicular cell sheet was significantly higher in hyperthyroid state than in euthyroid state (60.0% vs. 24.7%, p<0.05). High titers of antithyroglobulin antibody (>/= 320) and anti-thyroid microsomal antibody (>/= 1280) were more frequently seen in hypothyroid state than in euthyroid state (54.2% vs. 28.6%, p<0.05; 83.3% vs. 62.3%, p<0.05). There was no relationship between the cytomorphology and thyroid antibodies and the response to thyroxine treatment.
|Appears in Collections:||醫學系|
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