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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/188059
Title: Sensitivity of the Slow Component of the Delayed Rectifier Potassium Curren (Iks)Topotassium Channel Blockers: Implications for Clinical Reverse Use-Dependent Effect
Authors: LAI, LING-PING
Keywords: antiarrhythmic agents;potassium channels;voltage clamp;III ANTIARRHYTHMIC AGENTS;HUMAN VENTRICULAR MYOCYTES;HUMAN ATRIAL MYOCYTES
Issue Date: 1999
Journal Volume: v.6
Journal Issue: n.4
Start page/Pages: 251-259
Source: JOURNAL OF BIOMEDICAL SCIENCE 
Abstract: 
The slow delayed rectifier potassium current (I-Ks) is unique in its slow activation and deactivation kinetics. It is important during cardiac repolarization, especially when the heart rate is fast. We compared the effects of quinidine , procainamide, sotalol, and amiodarone on I-Ks and correlated the findings with the clinical reverse use- dependent effects of potassium channel blockers. Human minK RNA was obtained by reverse transcription-polymerase chain reaction using explanted human heart. The RNA was injected into Xenopus oocytes for heterologous expression of I-Ks. A two-electrode voltage clamp technique was performed to investigate the I-Ks. We demonstrated that quinidine, sotalol and procainamide had no effects on I-Ks up to a concentration of 300 mu M while amiodarone inhibited I-Ks in a concentration-dependent manner starting from 10 mu M. The inhibition by amiodarone was state-dependent with gradual unblocking after depolarization, The degree of inhibition was 53% immediately after depolarization and 19% at the end of a 5-second depolarization. I-Ks is 30 times more sensitive to amiodarone than to quinidine, sotalol, and procainamide, Quinidine, sotalol and procainamide have reverse use- dependent effects while amiodarone does not, This is compatible with the hypothesis that no inhibition of I-Ks at clinical concentrations contributes to the clinical reverse use-dependent effects.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/95103
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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