https://scholars.lib.ntu.edu.tw/handle/123456789/188059
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | LAI, LING-PING | en |
dc.creator | 賴凌平;曾淵如;連文彬;蘇銘嘉 | zh_TW |
dc.creator | LAI, LING-PING;TSENG, YUNG-ZU;LIEN, WEN-PIN;SU, MING-JAI | en |
dc.date | 1999 | en |
dc.date.accessioned | 2008-12-29T07:00:44Z | - |
dc.date.accessioned | 2018-07-11T05:20:45Z | - |
dc.date.available | 2008-12-29T07:00:44Z | - |
dc.date.available | 2018-07-11T05:20:45Z | - |
dc.date.issued | 1999 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95103 | - |
dc.description.abstract | The slow delayed rectifier potassium current (I-Ks) is unique in its slow activation and deactivation kinetics. It is important during cardiac repolarization, especially when the heart rate is fast. We compared the effects of quinidine , procainamide, sotalol, and amiodarone on I-Ks and correlated the findings with the clinical reverse use- dependent effects of potassium channel blockers. Human minK RNA was obtained by reverse transcription-polymerase chain reaction using explanted human heart. The RNA was injected into Xenopus oocytes for heterologous expression of I-Ks. A two-electrode voltage clamp technique was performed to investigate the I-Ks. We demonstrated that quinidine, sotalol and procainamide had no effects on I-Ks up to a concentration of 300 mu M while amiodarone inhibited I-Ks in a concentration-dependent manner starting from 10 mu M. The inhibition by amiodarone was state-dependent with gradual unblocking after depolarization, The degree of inhibition was 53% immediately after depolarization and 19% at the end of a 5-second depolarization. I-Ks is 30 times more sensitive to amiodarone than to quinidine, sotalol, and procainamide, Quinidine, sotalol and procainamide have reverse use- dependent effects while amiodarone does not, This is compatible with the hypothesis that no inhibition of I-Ks at clinical concentrations contributes to the clinical reverse use-dependent effects. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF BIOMEDICAL SCIENCE v.6 n.4 pp.251-259 | en |
dc.relation.ispartof | JOURNAL OF BIOMEDICAL SCIENCE | - |
dc.subject | antiarrhythmic agents | en |
dc.subject | potassium channels | en |
dc.subject | voltage clamp | en |
dc.subject | III ANTIARRHYTHMIC AGENTS | en |
dc.subject | HUMAN VENTRICULAR MYOCYTES | en |
dc.subject | HUMAN ATRIAL MYOCYTES | en |
dc.title | Sensitivity of the Slow Component of the Delayed Rectifier Potassium Curren (Iks)Topotassium Channel Blockers: Implications for Clinical Reverse Use-Dependent Effect | en |
dc.type | journal article | en |
dc.relation.pages | 251-259 | - |
dc.relation.journalvolume | v.6 | - |
dc.relation.journalissue | n.4 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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