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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/188060
Title: Down-Regulation of L-Type Calcium Channel and Sarcoplasmic Reticular Ca2+ -Atpase Mrna in Human Atrial Fibrillation without Significant Change in the Mrna of Ryanodine Receptor, Calsequestrin and Phospholamban
Authors: LAI, LING-PING
Keywords: EPIDEMIOLOGIC FEATURES;MODEL;VERAPAMIL;CURRENTS;CLONING;OUTWARD
Issue Date: 1999
Journal Volume: v.33
Journal Issue: n.5
Start page/Pages: 1231-1237
Source: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 
Abstract: 
OBJECTIVES We investigated the gene expression of calcium- handling genes including L-type calcium channel, sarcoplasmic reticular calcium adenosine triphosphatase (Ca2 +-ATPase), ryanodine receptor, calsequestrin and phospholamban in human atrial fibrillation. BACKGROUND Recent studies have demonstrated that atrial electrical remodeling in atrial fibrillation is associated with intracellular calcium overload. However, the changes of calcium-handling proteins remain unclear. METHODS A total of 34 patients undergoing open heart surgery were included. Atrial tissue was obtained from the right atrial free wall, right atrial appendage, left atrial free wall and left atrial appendage, respectively. The messenger ribonucleic acid (mRNA) amount of the genes was measured by reverse transcription-polymerase chain reaction and normalized to the mRNA levels of glyceraldehyde 3-phosphate dehydrogenase. RESULTS The mRNA of L-type calcium channel and of Ca2+- ATPase was significantly decreased in patients with persistent atrial fibrillation for more than 3 months (0.36+ /- 0.26 vs. 0.90 +/- 0.88 for L-type calcium channel; 0.69+/ - 0.42 vs. 1 .21 +/- 0.68 for Ca2+-ATPase; both p < 0.05, all data in arbitrary unit). We further demonstrated that there nas no spatial dispersion of the gene expression among the four atrial tissue sampling sites. Age, gender and underlying cardiac disease had no significant effects on the gene expression. In contrast, the mRNA levels of ryanodine receptor, calsequestrin and phospholamban showed no significant change in atrial fibrillation. CONCLUSIONS L- type calcium channel and the sarcoplasmic reticular Ca2+- ATPase gene were downregulated in atrial fibrillation. These changes may be a consequence of, as well as a contributory factor for, atrial fibrillation.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/95104
SDG/Keyword: [SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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