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  4. Measurement of Funny Current (If) Channel in Human Atrial Tissue: Correlation with Left Atrial Filling Pressure and Atrial Fibrillation.
 
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Measurement of Funny Current (If) Channel in Human Atrial Tissue: Correlation with Left Atrial Filling Pressure and Atrial Fibrillation.

Resource
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY v.10 n.7 pp.947-953
Journal
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Journal Volume
10
Journal Issue
7
Pages
947
Date Issued
1999
Date
1999
Author(s)
LING-PING LAI  
MING-JAI SU  
JIUNN-LEE LIN  
TSAI, CHANG-HER
LIN, FANG-YUE
CHEN, YIH-SHARNG
JUEY-JEN HWANG  
HUANG, SHOEI-K STEPHEN
TSENG, YUNG-ZU
LIEN, WEN-PIN
DOI
10.1111/j.1540-8167.1999.tb01265.x
URI
http://ntur.lib.ntu.edu.tw//handle/246246/95105
https://www.scopus.com/record/display.uri?eid=2-s2.0-0033033320&doi=10.1111%2fj.1540-8167.1999.tb01265.x&origin=inward&txGid=ad8f6901466c783b9514be0cf52f8675
Abstract
Introduction: The funny current (I-f)contributes to phase IV spontaneous depolarization in cardiac pacemaker tissue. Enhanced I-f activity in myocardial tissue may lead to increased automaticity and therefore tachyarrhythmia. We measured the amount of I-f activity in the messenger ribonucleic acid (mRNA) in human atrial tissue and correlated the mRNA amount to left atrial filling pressure and atrial fibrillation (AF). Methods and Results: A total of 34 patients undergoing open heart surgery were included ( 15 men and 19 women, aged 55 +/- 10 years). Atrial tissue was obtained from the right atrial free wall, the right atrial appendage, the left atrial free wall, and the left atrial appendage, respectively. The mRNA amount of the I-f channel was measured by reverse transcription polymerase chain reaction and was normalized to the mRNA levels of glyceraldehyde 3-phosphate dehydrogenase. We found that the I-f channel mRNA was present at all the atrial sampling sites. A higher left atrial filling pressure, an indicator of congestive heart failure, was associated with a higher I- f mRNA level (r(2) = 0.446, P < 0.01 by linear regression). We also found that the mRNA amount was significantly higher in patients with AF than in patients without AF (1.68 +/- 0 . 49 vs 1.27 + /- 0.43; P < 0.05). Age, sex, right atrial filling pressure, left atrial dimension, and left ventricular ejection fraction had no significant effect on the mRNA level. Conclusion: The mRNA of the I-f channel is present in the free-wall area and appendage area from both atria. Increased left atrial filling pressure and clinical AF are associated with increased I-f mRNA level.
Subjects
funny current
atrial fibrillation
left atrial filling pressure
RABBIT SINOATRIAL NODE
HYPERPOLARIZATION-ACTIVATED CURRENT
FAILING HUMAN HEARTS
Type
journal article

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