|Title:||Genetic Variation in Aldosterone Synthase Predicts Plasma Glucose Levels||Authors:||WU, KWAN-DUN
|Keywords:||QUANTITATIVE TRAIT LOCI;LOW-RENIN HYPERTENSION;BLOOD- PRESSURE;DIABETES-MELLITUS;FAMILIAL AGGREGATION;INSULIN- RESISTANCE||Issue Date:||2001||Journal Volume:||v.98||Journal Issue:||n.23||Start page/Pages:||13219-13224||Source:||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA||Abstract:||
The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between sing le- nucleotide polymorphisms in the alosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin, Two polymorphisms-one in the putative promoter (T-344 C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population-were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/ T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg- 173 and -344C homozygotes were most likely to be diabetic [ odds ratio 2.51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C. I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis.
|Appears in Collections:||醫學系|
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