血管張力素元與張力素轉化：基因多態型與冠狀動脈支架置放後再狹窄之關連

There are many reports
demonstrating the association of
renin-angiotensin system gene
polymorphisms with hypertension in
different populations. In the present study,
we used haplotype analyses of the
angiotensinogen gene with a new
permutation-based hypothesis testing
method to determine the association
between multilocus angiotensinogen
gene polymorphisms and hypertension in
a relatively homogeneous Taiwanese population.
We also genotyped
angiotensin converting enzyme gene
insertion/ deletion polymorphism and
angiotensin II type I receptor gene
A1166C polymorphism to detect epistatic
gene-gene interactions. There were 408
patients with hypertension (hypertensives)
and 286 controls. The angiotensinogen
gene haplotype frequencies were
significantly different between
hypertensives and controls, and this
finding was only present in subjects with
angiotensin converting enzyme gene II
genotypes when the analysis was
stratified by genotype of this
polymorphism. In addition, the
angiotensinogen gene hyplotype structure
of hypertensives was more
heterogeneous than that of controls. Our
results showed that angiotensinogen gene
haplotypes were associated with
hypertension, and might play a
synergistic action with I allele of
angiotensin converting enzyme gene.