肺癌轉移抑制基因—CRMP-1的上下游調控基因之分析(1/3)
Other Title
The upstream and downstream genes of CRMP-1, an invasion suppressor gene
Date Issued
2003
Date
2003
Author(s)
施金元
DOI
912314B002267
Abstract
Lung cancer is the leading cause of cancer
mortality in most countries, including
Taiwan. Metastasis is the most feared
manifestation hat defeats the present
modalities of treatments, such as surgery,
radiation and chemotherapy. We are
interested in studying specific mechanisms
involving the metastasis in lung cancer and
searching for new genes associated with the
invasion of lung cancer, in order to improve
the treatment modality. We used a
high-density cDNA microarray to identify
and then confirm CRMP-1 is an
invasion-suppressor genes. Accumulating
evidence has suggested that cancer cells
expressing higher levels of COX-2 would
obtain higher invasive abilities. CRMP-1 and
COX-2 seem to work in opposite way. This
study plans to investigate whether COX-2
would alter the cellular expression of
CRMP-1 in human lung adenocarcinoma cell
lines or vice versa. Preliminary results show
that COX-2 inhibitor induces the expression
of CRMP-1 and expression COX-2
suppresses the expression of CRMP-1.
Subjects
Lung adenocarcinoma
metastasis
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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