https://scholars.lib.ntu.edu.tw/handle/123456789/188206
標題: | 有白袍高血壓之中國人的基因研究(II) | 其他標題: | Study on the gene of Chinese with white coat hypertension (II) | 作者: | 曾淵如 | 關鍵字: | 白袍高血壓;血管張力素原;分子變體;染劑-終結物週期定序;white coat hypertension;angiotensinogen;molecular variant;dye-terminator cycle sequencing | 公開日期: | 2003 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | 本研究在探討有白袍高血壓人之血管 張力素原(angiotensinogen, AGT)之基因的 分子變體(molecular variant )。目前共有 64 位有白袍高血壓人納入研究對象,其中 有男性30 位、女性34 位,年齡介於22 至 72 歲。白袍高血壓之診斷依據隨機血壓及 移動式血壓。白袍高血壓之定義是隨機血 壓之收縮壓≥140mmHg 或舒張壓≥90mmHg ,或兩者,而移動式平均血壓之 收縮壓<140mmHg 及舒張壓<90mmHg 。 我們用染劑-終結物週期定序 (dye-terminator cycle sequencing )之快速 縮小定序法(mini-sequencing ),同時測定 每一受檢者之AGT gene 之M235T , T174M ,G-217A ,A-6G 分子變體。 本文為初步結果,進一步分析等待完 成。 This is to examine the molecular variant of the angiotensinogen (AGT) gene in subjects with white coat hypertension (WCH). A total of 64 subjects with WCH were studied. They were 30 men and 34 women. Their age ranged from 22 to 72 years. There were diagnosed by casual blood pressure and ambulatory blood pressure. The WCH is defined as an abnormally high causal blood pressure (SBP ≥140 mmHg or DBP ≥90 mmHg or both) and a normal ambulatory blood pressure average (SBP < 140 mmHg and DBP < 90 mmHg). We created a rapid mini-sequencing method based on dye-terminator cycle sequencing to detect the M235T, T174M, G-217A and A-6G variants of the AGT gene for each subject. The genotype and allele distribution of the M235T variant, the T174M, G-217A, and A-6G were analyzed. This is a preliminary result. Further data analysis remains to complete. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/23605 | 其他識別: | 912314B002285 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
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912314B002285.pdf | 43.27 kB | Adobe PDF | 檢視/開啟 |
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