https://scholars.lib.ntu.edu.tw/handle/123456789/188270
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | YANG, PEI-MING | en |
dc.contributor.author | 陳培哲 | zh-tw |
dc.creator | 楊培銘;黃麗華;陳培哲;陳定信;江伯倫 | zh-tw |
dc.creator | YANG, PEI-MING;HWANG, LIH-HWA;CHEN, PEI-JER;CHEN, DING-SHINN;CHIANG, BOR-LUEN | en |
dc.date | 2002 | en |
dc.date.accessioned | 2008-12-29T07:16:19Z | - |
dc.date.accessioned | 2018-07-11T05:28:30Z | - |
dc.date.available | 2008-12-29T07:16:19Z | - |
dc.date.available | 2018-07-11T05:28:30Z | - |
dc.date.issued | 2002 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95218 | - |
dc.description.abstract | The aim of this study was to further investigate the role of T-helper cells in hepatitis C virus (HCV) infection, focusing on the T-cell antigenic determinants and cytokine profiles of nonstructural 3 (NS3) protein-stimulated peripheral blood mononuclear cells (PBMCs) of HCV patients. A total of 12 recombinant proteins of theNS3 region were purified and used to test T-cell proliferative response and antigenic determinants of HCV-seropositive patients. In addition, cytokines produced by antigen stimulated PBMCs were measured. Our data showed that PBMCs from 55.7% (34/61) of HCV patients proliferated to at least one antigen, but PBMCs of HCV seronegative patients did not. In addition, PBMCs from about 82.0% (32/39) HCV-seropositive patients produced significant amounts of cytokines (10 pg/mL). Interestingly, PBMCs from 66% of patients produced TH2 - related cytokines such as interleukin (IL)-4 and IL-5. In mappingexperiments, the data showed multiple T-cell antigenic determinants . Our data demonstrated that NS3 antigen-stimulated PBMCs of HCV patients recognized multiple T-cell antigenic determinants and produced significant amounts of TH0 or TH2 -related cytokines, which might play a critical role in the chronicity of HCV infection. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF VIRAL HEPATITIS v.9 n.4 pp.258-264 | en |
dc.relation.ispartof | JOURNAL OF | - |
dc.subject | cytokines | en |
dc.subject | hepatitis C virus | en |
dc.subject | T-helper cell | en |
dc.subject | NS3 PROTEIN | en |
dc.subject | NON-A | en |
dc.subject | INFECTION | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | T-Cell Antigenic Determinants within Hepatitis C Virus Nonstructural Protein 3 and Cytokine Production Profiles in Hepatitis C | en |
dc.type | journal article | en |
dc.relation.pages | 258-264 | - |
dc.relation.journalvolume | VIRAL | - |
dc.relation.journalissue | n.4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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