https://scholars.lib.ntu.edu.tw/handle/123456789/188311
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | TAI, TONG-YUAN | en |
dc.contributor.author | LU, JIN-YNG | en |
dc.contributor.author | CHEN, CHI- LONG | en |
dc.contributor.author | LAI, MING-YANG | en |
dc.contributor.author | CHEN, PEI-JER | en |
dc.contributor.author | KAO, JIA-HORNG | en |
dc.contributor.author | 陳培哲 | zh_TW |
dc.creator | 戴東原;呂金盈;陳志榮;賴明陽;陳培哲;高嘉宏;李嘉哲;李宣書;莊立民;鄭永銘 | zh_TW |
dc.creator | TAI, TONG-YUAN;LU, JIN-YNG;CHEN, CHI- LONG;LAI, MING-YANG;CHEN, PEI-JER;KAO, JIA-HORNG;LEE, CHA-ZE;LEE, HSUAN-SHU;CHUANG, LEE-MING;JENG, YUNG-MING | en |
dc.date | 2003 | en |
dc.date.accessioned | 2008-12-29T07:21:58Z | - |
dc.date.accessioned | 2018-07-11T05:29:57Z | - |
dc.date.available | 2008-12-29T07:21:58Z | - |
dc.date.available | 2018-07-11T05:29:57Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95260 | - |
dc.description.abstract | This study aimed at elucidating the effects of interferon ( IFN)-alpha on glucose metabolism in patients with chronic hepatitis B and C infections. Twenty-eight biopsy-proven patients with chronic hepatitis B (ten cases) and hepatitis C (18 cases) were given IFN-alpha for a total of 24 weeks. The patients received a 75 g oral glucose tolerance test ( OGTT), glucagon stimulation test, tests for type 1 diabetes- related autoantibodies and an insulin suppression test before and after IFN-alpha therapy. Ten of the 28 patients responded to IFN-alpha therapy. Steady-state plasma glucose of the insulin suppression test decreased significantly in responders (13. 32 +/- 1.48 (S.E.M.) vs 11.33 +/- 1.19 mmol/l , P=0.0501) but not in non- responders (12.29 +/- 1.24 vs 11. 11 +/- 0.99 mmol/l, P=0.2110) immediately after completion of IFN-alpha treatment. In the oral glucose tolerance test, no significant difference was observed in plasma glucose in either responders (10.17 +/- 0.23 vs 10.03 +/- 0.22 mmol/l) or non- responders (10.11 +/- 0.22 vs 9.97 +/- 0.21 mmol/l) 3 months after completion of IFN-alpha treatment. However, significant differences were noted in C-peptide in both responders (2.90 +/- 0.13 vs 2.20 +/- 0.09 nmol /l, P=0.0040) and non-responders (2.45 +/- 0.11 vs 2.22 +/- 10.08 nmol/l, P=0.0287) before vs after treatment. The changes of C- peptide in an OGTT between responders and non-responders were also significantly different (P =0.0028), with responders reporting a greater reduction in C-peptide. No case developed autoantibodies during the treatment. In patients who were successfully treated with IFN-alpha, insulin sensitivity improved and their plasma glucose stayed at the same level without secreting as much insulin from islet beta-cells. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF ENDOCRINOLOGY v.178 n.3 pp.457-465 | en |
dc.relation.ispartof | JOURNAL OF ENDOCRINOLOGY | - |
dc.subject | CHRONIC ACTIVE HEPATITIS | en |
dc.subject | HOMEOSTASIS MODEL ASSESSMENT | en |
dc.subject | TYPE-1 DIABETES-MELLITUS | en |
dc.subject | CHRONIC VIRAL-HEPATITIS | en |
dc.subject | GLUCOSE-TOLERANCE | en |
dc.subject | LIVER-DISEASE | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Interferon-Alpha Reduces Insulin Resistance and Beta-Cell Secretion in Responders among Patients with Chronic Hepatitis B and C | en |
dc.type | journal article | en |
dc.relation.pages | 457-465 | - |
dc.relation.journalvolume | v.178 | - |
dc.relation.journalissue | n.3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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