https://scholars.lib.ntu.edu.tw/handle/123456789/188325
標題: | 胰島素抗阻、糖尿病與肥胖相關基因之研究 | 其他標題: | Study on the genes related to insulin resistance, type 2 diabetes and obesity | 作者: | 莊立民 | 關鍵字: | 代謝症候群;mRNA 表現;單核甘酸多樣型;APM1;SORBS1;PPAR;metabolic syndrome;mRNA expression;SNP;PPAR | 公開日期: | 2003 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | 糖尿病是一種常見的新陳代謝失調,估計至少佔世界人口的5%。在台灣糖尿病 的盛行率約為4%,其中95%以上之患者為第二型糖尿病;第二型糖尿病經常與 肥胖、高血壓、血脂不良症及動脈硬化症同時存在,據世界衛生組織估計,下 個十年75 %的醫療花費將用在非傳染性之慢性疾病上。這些異常含有第二型糖 尿病、肥胖、高血壓、血脂不良症、冠狀動脈疾病,以上全部統稱為代謝症候 群,今年我們計畫分析引發這些疾病的致病路徑主要缺陷,即胰島素阻抗性, 經過修正著重目標在: 在此提案第一年的具體的研究: 尋找候補基因之SNPs ,並確定其與胰島素阻抗性及相關臨床第二型糖尿病、肥 胖及冠狀動脈疾病之關係。 我們在臨床結合基因學之研究,顯示與APM1 基因的SNP 與胰島素阻抗性有關 連,並與PPAR 基因型產生交互作用,影響肥胖與胰島素阻抗性(APM1 與肥 胖關係之研究,已被JMM 接受刊登,而APM1 與 PPAR 基因之交互作用, 也已被Diabetologia 接受刊登)。 更重要的是,我們研究APM1 基因之對偶基因之表達,和SORBS1 基因在脂肪 組織的表達,與肥胖或胰島素阻抗性有密切之關連(前者在JMM 中刊登,而後 者則在Ob Res 刊登)。 經由本年的研究發現有更多的有興趣的基因標記,並與臨床複雜的疾病有關,如 代謝症候群。此經驗可提供未來大規模的基因型分析,得出更多的數據資料,以 達到對糖尿病與代謝症候群更深入之瞭解。 Type 2 diabetes is one of the most common metabolic disorders affecting at least 5% of the whole population in the world. In Taiwan, the prevalence of diabetes mellitus was about 4% and more than 95% of the cases were type 2 diabetes mellitus. Since type 2 diabetes is frequently associated with obesity, hypertension, dyslipidemia and atherosclerosis, it has been projected by the WHO that more than 75% of the health cost will be consumed for the non-communicable disease (NCD) in the next decade. The underlying cause of these abnormalities including type 2 diabetes, obesity, hypertension, dyslipidemia and coronary artery disease, collectively termed metabolic syndrome, is not well understood. However, it has been clearly shown that both environmental and genetic factors are important in the pathogenesis of metabolic syndrome. In this year (of the originally proposed 3-year project), we planed to dissect pathogenic pathways leading to the major defect underlying the metabolic syndrome, i.e. insulin resistance. With the revision, we focus only on some the targets: Specific research of this proposal in the first year granted: Isolation of the SNPs of the candidate genes and confirm the association with insulin resistance and the related clinical disorders such as type 2 diabetes, obesity and coronary artery disease in Chinese population. We have confirmed by clinical association studies to show a positive correlation of SNP of the APM1 gene and its interaction with PPAR gene in subjects with obesity and insulin resistance (A study on APM1 locus with obesity and different allelic expressions in the adipose tissue has been accepted by JMM; A study on gene-to-gene interaction between APM1 and PPAR has been accepted by Dia betologia). More importantly, we showed the allele-specific expression of APM1 gene and expression of SORBS1 gene in the adipose tissue to correlate clinical obesity and insulin sensitivity (A study on tissue expression of SORBS1 gene correlated with clinical phenotype has been accepted by Ob Res; A study on APM1 locus with obesity and different allelic expressions in the adipose tissue has been accepted by JMM). Currently, we have identified more interesting genetic markers that might be related to clinical complex disorder such as the metabolic syndrome. Future large-scale genotyping might yield more remarkable data via high throughput genome center. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/23624 | 其他識別: | 913112B002019 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
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913112B002019.pdf | 6.69 MB | Adobe PDF | 檢視/開啟 |
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