https://scholars.lib.ntu.edu.tw/handle/123456789/188380
標題: | 急性白血病之多色分光染色體核型分析(2/2) | 其他標題: | NPM Mutations in de novo Acute Myeloid Leukemia: the Mutation Occurs Much More Frequently in Adults than in Children and Is Closely Associated with Disease Status(2/2) | 作者: | 田蕙芬 | 關鍵字: | NPM;AML;CEBPA;FLT3/ITD;immunophenotype | 公開日期: | 2005 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | NPM mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially in those of a normal karyotype. These results provide a basis for studies of the pathogenesis in this specific subgroup of AML. In this study, NPM mutations were analyzed in 173 de novo AML patients including adults and children. We found NPM mutations were present in 19.1% of the overall population and 40.3% of those with a normal karyotype. Adults had a significantly higher incidence of NPM mutations than children (32/126, 25.4% vs. 1/47, 2.1%, p<0.001). NPM mutations were closely associated with normal karyotype (p<0.001) and FLT3/ITD (p=0.002), but negatively associated with CEBPA mutations (p=0.032) and expression of CD34 (p<0.001) and HLA-DR (p=0.003). Serial analyses of NPM mutations showed the mutation disappeared at complete remission, but the same mutation reappeared at relapse, except for one who lost the mutation at the second relapse, when new cytogenetic abnormalities emerged. None acquired novel mutations during the follow-up period. In conclusion, NPM mutations occur in an age-dependent fashion. The findings that NPM mutations are stable during disease evolution and closely associated with disease status make it a potential marker for monitoring minimal residual disease. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/23685 | 其他識別: | 932314B002039 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
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932314B002039.pdf | 481.47 kB | Adobe PDF | 檢視/開啟 |
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