https://scholars.lib.ntu.edu.tw/handle/123456789/188417
標題: | 國人肺腺癌之基礎與臨床研究─黏液素蛋白表現與肺癌之關係 | 作者: | 余忠仁 | 關鍵字: | GMucin glycoprotein;mucin gene;monoclonal antibody;polyclonal antibody;lung cancer | 公開日期: | 1999 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | Aberrant expression of mucins and mucin related antigens are noted to be poor survival factors in cancer. Experimentally, mucins had been demonstrated to promote tumor cell invasion, metastasis and modulate the immune recognition phenomenon of cancer cells. Only few studies have addressed the prognostic implications of mucin and mucin associated antigens in lung cancer. Our previous investigations had discovered the association among lung adenocarcinoma, sialomucin and Muc5AC expression. Therefore, to study the regulation of Muc5AC protein expression should be an important topic in investigating lung cancer. In order to study the protein expression of Muc5AC in lung cancer, 20 kD fusion protein of Muc5AC nontandem repeat sequence was made, injected into animals (chicken, and mice), and successfully generated anti-Muc5AC polyclonal and monoclonal antibodies. These antibodies were applied in the immunohistochemistry, western blotting of variable specimens of lung cancer, as well as ELISA assay. The results are unsatisfactory. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/29761 | 其他識別: | 882314B002083M39 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
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882314B002083M39.pdf | 255.65 kB | Adobe PDF | 檢視/開啟 |
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