https://scholars.lib.ntu.edu.tw/handle/123456789/188425
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | CHAN, PAUL | en |
dc.contributor.author | CHEN, JIN-JER | en |
dc.contributor.author | LEE, HORNG-MO | en |
dc.contributor.author | LEE, WEN-SEN | en |
dc.contributor.author | SHIH, NENG-LANG | en |
dc.creator | 陳保羅;陳錦澤;李宏謀;李文森;施能明 | zh_TW |
dc.creator | CHAN, PAUL;CHEN, JIN-JER;LEE, HORNG-MO;LEE, WEN-SEN;SHIH, NENG-LANG | en |
dc.date | 2004 | en |
dc.date.accessioned | 2008-12-29T07:24:12Z | - |
dc.date.accessioned | 2018-07-11T05:34:43Z | - |
dc.date.available | 2008-12-29T07:24:12Z | - |
dc.date.available | 2018-07-11T05:34:43Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95277 | - |
dc.description.abstract | The myocardial protective effects of trilinolein, isolated from the traditional Chinese herb Sanchi ( Panax notoginseng ), are thought to be related to its antioxidant activity. However, the intracellular mechanism underlying the protective effect of trilinolein in the heart remains unclear. In the present study, we investigated the effect of trilinolein on norepinephrine (NE)-induced protein synthesis in cardiomyocytes. Cultured neonatal rat cardiomyocytes were stimulated with NE, then protein content , [H-3]-leucine incorporation, and beta-myosin heavy chain ( beta -MyHC) promoter activity were examined. The effect of trilinolein on NE- induced intracellular reactive oxygen species (ROS) generation was measured with a redox-sensitive fluorescent dye (2', 7'-dichlorofluorescin diacetate) and extracellular signal-regulated kinase (ERK) phosphorylation by Western blotting. Trilinolein inhibited NE-increased protein synthesis, beta-MyHC promoter activity, and intracellular ROS. Both trilinolein and the antioxidant, N- acetyl-cysteine, decreased NE- and H2O2-induced protein synthesis, beta-MyHC promoter activity, and ERK phosphorylation. These data indicate that trilinolein inhibits NE- induced protein synthesis via attenuation of ROS generation in cardiomyocytes. Copyright (C) 2004 National Science Council, ROC and S. Karger AG, Basel. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF BIOMEDICAL SCIENCE v.11 n.1 pp.11-18 | en |
dc.relation.ispartof | JOURNAL OF BIOMEDICAL SCIENCE | - |
dc.subject | norepinephrine | en |
dc.subject | trilinolein | en |
dc.subject | reactive oxygen species | en |
dc.subject | extracellular signal-regulated kinase | en |
dc.subject | beta-myosin heavy chain gene | en |
dc.title | The Inhibitory Effect of Trilinolein on Norepinephrine-Induced Beta- Myosin Heavy Chain Promoter Activity, Reactive Oxygen Species Generation, and Extracellular Signal-Regulated Kinase Phosphorylation in Neonatal Rat Cardiomyocytes | en |
dc.type | journal article | en |
dc.relation.pages | 11-18 | - |
dc.relation.journalvolume | v.11 | - |
dc.relation.journalissue | n.1 | - |
item.languageiso639-1 | en_US | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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