https://scholars.lib.ntu.edu.tw/handle/123456789/188440
標題: | Sialyl Lewis Antigens: Association with Muc5ac Protein and Correlation with Post-Operative Recurrence of Non-Small Cell Lung Cancer | 作者: | YU, CHONG-JEN 楊泮池 |
關鍵字: | Lung cancer;Carbohydrate antigen;Mucin;Glycosylation | 公開日期: | 2005 | 卷: | v.47 | 期: | n.1 | 起(迄)頁: | 59-67 | 來源出版物: | LUNG CANCER | 摘要: | Sialyl Lewis antigens (sLex/a) are cancer-associated carbohydrate determinants, serve as ligands of the selectin family and are associated with hematogenous metastasis of cancer. So far, the clinicopathologic values of sialyl Lewis x (sLex) and sialyl Lewis a (sLea) in lung cancer have remained controversial. Using immunohistochemistry, the expressions of sLex and sLea antigens, and an airway mucin ( MUC5AC) protein, which was supposed to be the major carrying protein of sialyl Lewis moieties, were studied in surgically resected tumor tissues of 61 patients with stages I or II NSCLC. Thirty-two (52.5%) of the 61 studied subjects were found to be positive for expression of sLea, 40 (65.6%) were positive for expression of sLex, and 16 (26. 2%) were positive for MUC5AC protein. Both the expression of sLex and MUC5AC were associated with adenocarcinoma subtype. Patients bearing tumors with MUC5AC and/or sLex expression had a higher probability of post-operative distant metastasis. Survival analysis demonstrated that patients bearing tumors with expression of sLex antigen or MUC5AC had shorter overall survival. The multivariate logistic regression showed that age >65 years old (OR = 0. 207, 95% CI= 0.075–0. 569, P = 0.002), nodal status (OR = 6. 575, 95% CI = 2.459–17.583, P < 0. 001), and MUC5AC (OR = 5 . 545, 95% CI = 1.998–15.386, P = 0.001) were independent factors affecting survival. We concluded that the expression of sLex was related to MUC5AC protein, while patients with tumors co- expressing both MUC5AC and sLex antigen had the worst survival. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/95292 |
顯示於: | 醫學系 |
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