https://scholars.lib.ntu.edu.tw/handle/123456789/189528
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | YANG, PAN-CHYR | en |
dc.creator | 楊泮池 | zh-tw |
dc.creator | YANG, PAN-CHYR | en |
dc.date | 2006 | en |
dc.date.accessioned | 2009-09-29T04:48:29Z | - |
dc.date.accessioned | 2018-07-11T06:13:33Z | - |
dc.date.available | 2009-09-29T04:48:29Z | - |
dc.date.available | 2018-07-11T06:13:33Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/93119 | - |
dc.description.abstract | This study compared the efficacy and safety of budesonide/ formoterol ( Symbicort (R) Turbuhalere (R)) with salbutamol pressurized metered-dose inhaler (pMDI) with spacer for relief of acute bronchoconstriction in patients with asthma. In this randomized. double-blind. parallel-group study, patients (n = 104 allocated to treatment; n = 103 received treatment: mean age 45 years) seeking medical attention for acute asthma ( mean FEV1 43% of predicted) received two doses repeated at t = -5 and 0 min of either budesonide/ formoterol (320/9 mu g, two inhalations) or salbutamol (100 mu g x eight inhalations); total doses 1280/36 mu g and 1600 mu g, respectively. All patients received prednisolone 60 mg at 90 min and FEV1 was assessed over 3 h. FEV1 90 min after dosing (primary variable) increased compared with pre- dose FEV1 by an average of 30% and 32% for budesonide/ formoterol and salbutamol, respectively (P = 0.66), with similar increases at all timepoints from 3 to 180 min for both groups . Mean pulse rate over 3 h was significantly higher in the salbutamol group versus the budesonide/ formoterol group (92 vs. 88 bpm; P < 0.01). No treatment differences were seen for other vital signs, including ECG. High-dose budesonide/formoterol was effective and well tolerated for the treatment of acute asthma, with rapid onset of efficacy and a safety profile over 3 h similar to high-dose salbutamol. (c) 2005 Elsevier Ltd. All rights reserved. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | PULMONARY PHARMACOLOGY & THERAPEUTICS v.19 n.2 pp.139-147 | en |
dc.relation.ispartof | PULMONARY PHARMACOLOGY & THERAPEUTICS | - |
dc.subject | asthma | en |
dc.subject | budesonide/formoterol | en |
dc.subject | Symbicort® | en |
dc.subject | reliever medication | en |
dc.title | Efficacy and Safety of Budesonide/Formoterol Compared with Salbutamol in the Treatment of Acute Asthma | en |
dc.type | journal article | en |
dc.relation.pages | 139-147 | - |
dc.relation.journalvolume | v.19 | - |
dc.relation.journalissue | n.2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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