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  2. 醫學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/189636
Title: Magnolol Depresses Urotensin-Ii-Induced Cell Proliferation in Rat Cardiac Fibroblasts
Authors: LIOU, JER-YOUNG
CHEN, YEN-LING
LOH, SHIH-HURNG
HUANG, CHENG-HSIUNG
CHEN, JIN-JER
CHENG, TZU-HURNG
LIU, JU-CHI
LIU, JU- CHI
Keywords: cardiac fibroblasts;endothelin-1;extracellular signal- regulated kinase;magnolol;reactive oxygen species;U-II
Issue Date: 2009
Start page/Pages: 711-716
Source: Clinical and Experimental Pharmacology and Physiology 
Abstract: 
P>Accumulating evidence suggests that oxidative stress plays a key role in the development of cardiac fibrosis. Urotensin-II (U-II) has been reported to play an important role in cardiac remodelling and fibrosis. Recently, we demonstrated the involvement of reactive oxygen species (ROS ) production in U-II-induced cardiac fibroblast proliferation. Magnolol is an anti-oxidant compound extracted from the cortices of Magnolia officinalis. Thus, it is feasible that magnolol may attenuate cardiac fibroblast proliferation by inhibiting ROS production. Therefore, the aims of the present study were to determine whether magnolol alters U-II- induced cell proliferation and to identify the putative underlying signalling pathways in rat cardiac fibroblasts. Cultured rat cardiac fibroblasts were pretreated with magnolol (1, 3 and 10 mu mol/L) for 30 min, followed by exposure to U-II (30 nmol/L) for 24 h, after which cell proliferation and endothelin-1 (ET-1) protein secretion was examined. The effects of magnolol on U -II-induced ROS formation and extracellular signal-regulated kinase (ERK) phosphorylation were examined to elucidate the intracellular mechanisms by which magnolol affects cell proliferation and ET-1 expression. Urotensin-II (30 nmol/L) stimulated cell proliferation, ET-1 protein secretion and ERK phosphorylation, all of which were inhibited by magnolol (10 mu mol/L). Pretreatment of cardiac fibroblasts with N- acetylcysteine (5 mmol/L) for 30 min prior to exposure to U- II resulted in inhibition of U-II increased ROS formation. Similar effects were observed with 10 mu mol/L magnolol. In conclusion, the results suggest that magnolol inhibits cardiac fibroblast proliferation by interfering with ROS generation. Thus, the present study provides important new insights into the molecular pathways involved, which may contribute to our understanding of the effects of magnolol on the cardiovascular system.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/185819
DOI: 10.1111/j.1440-1681.2009.05144.x
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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