https://scholars.lib.ntu.edu.tw/handle/123456789/189877
Title: | Incidence of Acute Pancreatitis in Human Immunodeficiency Virus-Positive Patients With Hypertriglyceridemia Is It Really High? | Authors: | Sun, Hsin-Yun Chang, Sui-Yuan Sheng, Wang-Huei Chen, Mao-Yuan Hsieh, Szu-Min Tseng, Yu-Tzu Lu, Ching-Lan Yang, Chia-Jui Wu, Hsiu Liu, Wen-Chun Wu, Cheng-Hsin Hung, Chien-Ching Chang, Shan-Chwen 吳政翰 |
Keywords: | human immunodeficiency virus;highly active antiretroviral therapy;hypertriglyceridemia;acute pancreatitis;incidence rate | Issue Date: | 2012 | Journal Volume: | 41 | Journal Issue: | 2 | Start page/Pages: | 283-289 | Source: | Pancreas | Abstract: | Objective: To assess the incidence of acute pancreatitis in human immunodeficiency virus-positive patients with triglyceride (TG) greater than 500 mg/dL after highly active antiretroviral therapy. Methods: Sequential TG levels during follow-up and episodes of acute pancreatitis were retrospectively reviewed in 347, 417, and 571 patients enrolled in periods 1 (2000-2002), 2 (2003-2005), and 3 (2006-2008), respectively. The incidence of acute pancreatitis, defined as consistent clinical symptoms and elevated amylase and/or lipase levels, was estimated. Results: A total of 5356 TG measurements were performed during the follow-up for 698.22, 884.14, and 1215.69 person-years in periods 1, 2, and 3, respectively. Overall, 9.89% of patients had at least one TG greater than 500 mg/dL. Five patients with TG less than 500 mg/dL developed acute pancreatitis. The crude incidences of acute pancreatitis were 0.6%, 0.5%, and 0.2%, and the incidence rates were 2.86, 2.26, and 0.82/1000 person-years in periods 1, 2 and 3, respectively (all, P > 0.05). The incidence rates of acute pancreatitis when TG levels were less than 500, less than 1000, and less than 1500 mg/dL ranged from 1.2 to 4.9/1000 person-years, whereas it was 0/1000 person-years when TG levels were greater than 500, greater than 1000, and greater than 1500 mg/dL, respectively. Conclusion: The risk of acute pancreatitis was low among human immunodeficiency virus-positive patients who developed hypertriglyceridemia after receiving highly active antiretroviral therapy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/258754 | SDG/Keyword: | [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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