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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/189877
Title: Incidence of Acute Pancreatitis in Human Immunodeficiency Virus-Positive Patients With Hypertriglyceridemia Is It Really High?
Authors: Sun, Hsin-Yun
Chang, Sui-Yuan
Sheng, Wang-Huei
Chen, Mao-Yuan
Hsieh, Szu-Min
Tseng, Yu-Tzu
Lu, Ching-Lan
Yang, Chia-Jui
Wu, Hsiu
Liu, Wen-Chun
Wu, Cheng-Hsin
Hung, Chien-Ching
Chang, Shan-Chwen
吳政翰
Keywords: human immunodeficiency virus;highly active antiretroviral therapy;hypertriglyceridemia;acute pancreatitis;incidence rate
Issue Date: 2012
Journal Volume: 41
Journal Issue: 2
Start page/Pages: 283-289
Source: Pancreas 
Abstract: 
Objective: To assess the incidence of acute pancreatitis in human immunodeficiency virus-positive patients with triglyceride (TG) greater than 500 mg/dL after highly active antiretroviral therapy.
Methods: Sequential TG levels during follow-up and episodes of acute pancreatitis were retrospectively reviewed in 347, 417, and 571 patients enrolled in periods 1 (2000-2002), 2 (2003-2005), and 3 (2006-2008), respectively. The incidence of acute pancreatitis, defined as consistent clinical symptoms and elevated amylase and/or lipase levels, was estimated.
Results: A total of 5356 TG measurements were performed during the follow-up for 698.22, 884.14, and 1215.69 person-years in periods 1, 2, and 3, respectively. Overall, 9.89% of patients had at least one TG greater than 500 mg/dL. Five patients with TG less than 500 mg/dL developed acute pancreatitis. The crude incidences of acute pancreatitis were 0.6%, 0.5%, and 0.2%, and the incidence rates were 2.86, 2.26, and 0.82/1000 person-years in periods 1, 2 and 3, respectively (all, P > 0.05). The incidence rates of acute pancreatitis when TG levels were less than 500, less than 1000, and less than 1500 mg/dL ranged from 1.2 to 4.9/1000 person-years, whereas it was 0/1000 person-years when TG levels were greater than 500, greater than 1000, and greater than 1500 mg/dL, respectively.
Conclusion: The risk of acute pancreatitis was low among human immunodeficiency virus-positive patients who developed hypertriglyceridemia after receiving highly active antiretroviral therapy.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/258754
SDG/Keyword: [SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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