Incidence of Acute Pancreatitis in Human Immunodeficiency Virus-Positive Patients With Hypertriglyceridemia Is It Really High?
Resource
Pancreas, 41(2), 283-289
Journal
Pancreas
Journal Volume
41
Journal Issue
2
Pages
283-289
Date Issued
2012
Date
2012
Author(s)
Sun, Hsin-Yun
Chang, Sui-Yuan
Sheng, Wang-Huei
Chen, Mao-Yuan
Hsieh, Szu-Min
Tseng, Yu-Tzu
Lu, Ching-Lan
Yang, Chia-Jui
Wu, Hsiu
Liu, Wen-Chun
Wu, Cheng-Hsin
Hung, Chien-Ching
Chang, Shan-Chwen
Abstract
Objective: To assess the incidence of acute pancreatitis in human immunodeficiency virus-positive patients with triglyceride (TG) greater than 500 mg/dL after highly active antiretroviral therapy.
Methods: Sequential TG levels during follow-up and episodes of acute pancreatitis were retrospectively reviewed in 347, 417, and 571 patients enrolled in periods 1 (2000-2002), 2 (2003-2005), and 3 (2006-2008), respectively. The incidence of acute pancreatitis, defined as consistent clinical symptoms and elevated amylase and/or lipase levels, was estimated.
Results: A total of 5356 TG measurements were performed during the follow-up for 698.22, 884.14, and 1215.69 person-years in periods 1, 2, and 3, respectively. Overall, 9.89% of patients had at least one TG greater than 500 mg/dL. Five patients with TG less than 500 mg/dL developed acute pancreatitis. The crude incidences of acute pancreatitis were 0.6%, 0.5%, and 0.2%, and the incidence rates were 2.86, 2.26, and 0.82/1000 person-years in periods 1, 2 and 3, respectively (all, P > 0.05). The incidence rates of acute pancreatitis when TG levels were less than 500, less than 1000, and less than 1500 mg/dL ranged from 1.2 to 4.9/1000 person-years, whereas it was 0/1000 person-years when TG levels were greater than 500, greater than 1000, and greater than 1500 mg/dL, respectively.
Conclusion: The risk of acute pancreatitis was low among human immunodeficiency virus-positive patients who developed hypertriglyceridemia after receiving highly active antiretroviral therapy.
Subjects
human immunodeficiency virus
highly active antiretroviral therapy
hypertriglyceridemia
acute pancreatitis
incidence rate
SDGs
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