|Title:||Safety Issues of Long-Term Glucose Load in Patients on Peritoneal Dialysis-A 7-Year Cohort Study||Authors:||Wu, Hon-Yen
|Issue Date:||2012||Journal Volume:||7||Journal Issue:||1||Start page/Pages:||-||Source:||PLoS One||Abstract:||
Background: Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival.
Methods: We surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates.
Results: We noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival.
Conclusions: Long-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.
|Appears in Collections:||醫學系|
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