https://scholars.lib.ntu.edu.tw/handle/123456789/190035
標題: | Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010 | 作者: | Ho, Cheng-Mao Ho, Mao-Wang Liu, Yung-Ching Toh, Han-Siong Lee, Yu-Lin Liu, Yuag-Meng Huang, Chi-Chang Lug, Po-Liang Liu, Chun-Eng Chen, Yen-Hsu Ko, Wen-Chien Tang, Hung-Jen Yu, Kwok-Woon Chen, Yao-Shen Chuang, Yin-Ching Wang, Jen-Hsien Hsueh, Po-Ren |
關鍵字: | Enterobacteriaceae;Intra-abdominal infections;Carbapenem resistance;Carbapenem consumption;SMART | 公開日期: | 2012 | 期: | 40 | 起(迄)頁: | - | 來源出版物: | Int. J. Antimicrob. Agents | 摘要: | We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of non-susceptibility ranged from 3.5% to 10.3% and those for imipenem ranged from 3.5% to 10.7%. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/258913 |
顯示於: | 醫學系 |
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