Insulin use is not significantly predictive for prostate cancer mortality in diabetic patients: a 12-year follow-up study
Resource
BJU Int., 110(5), 668-673
Journal
BJU Int.
Journal Volume
110
Journal Issue
5
Pages
668-673
Date Issued
2012
Date
2012
Author(s)
Tseng, Chin-Hsiao
Abstract
OBJECTIVE
To evaluate whether insulin use in diabetic patients could be predictive for prostate cancer mortality.
PATIENTS AND METHODS
A total of 39 135 diabetic men aged >= 40 years from a nationally representative cohort were followed prospectively from 1995 to 2006 for prostate cancer mortality.
Cox proportional hazards models were used to estimate the hazard ratios for the following independent variables: age, diabetes type, diabetes duration, body mass index, smoking, insulin use and area of residence.
The models were created for patients aged >= 40 years and >= 65 years, separately; and before and after excluding patients with a duration between onset of diabetes and prostate cancer mortality <5 years.
RESULTS
A total of 105 diabetic men died of prostate cancer during follow-up.
Age was the only significant risk factor.
Insulin use was associated with an insignificantly higher risk of prostate cancer mortality ranging from 24% to 49%.
When stratified by the duration of insulin use < 5 and >= 5 years, a lack of significant association was also observed.
CONCLUSIONS
Insulin use in diabetic patients does not significantly predict the mortality from prostate cancer.
Further confirmation in other ethnicities is needed.
Subjects
prostate cancer
insulin
type 2 diabetes mellitus
mortality
Taiwan
SDGs
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