|Title:||Insulin use is not significantly predictive for prostate cancer mortality in diabetic patients: a 12-year follow-up study||Authors:||Tseng, Chin-Hsiao||Keywords:||prostate cancer;insulin;type 2 diabetes mellitus;mortality;Taiwan||Issue Date:||2012||Journal Volume:||110||Journal Issue:||5||Start page/Pages:||668-673||Source:||BJU Int.||Abstract:||
To evaluate whether insulin use in diabetic patients could be predictive for prostate cancer mortality.
PATIENTS AND METHODS
A total of 39 135 diabetic men aged >= 40 years from a nationally representative cohort were followed prospectively from 1995 to 2006 for prostate cancer mortality.
Cox proportional hazards models were used to estimate the hazard ratios for the following independent variables: age, diabetes type, diabetes duration, body mass index, smoking, insulin use and area of residence.
The models were created for patients aged >= 40 years and >= 65 years, separately; and before and after excluding patients with a duration between onset of diabetes and prostate cancer mortality <5 years.
A total of 105 diabetic men died of prostate cancer during follow-up.
Age was the only significant risk factor.
Insulin use was associated with an insignificantly higher risk of prostate cancer mortality ranging from 24% to 49%.
When stratified by the duration of insulin use < 5 and >= 5 years, a lack of significant association was also observed.
Insulin use in diabetic patients does not significantly predict the mortality from prostate cancer.
Further confirmation in other ethnicities is needed.
|Appears in Collections:||醫學系|
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