https://scholars.lib.ntu.edu.tw/handle/123456789/190137
標題: | Insulin use is not significantly predictive for prostate cancer mortality in diabetic patients: a 12-year follow-up study | 作者: | Tseng, Chin-Hsiao | 關鍵字: | prostate cancer;insulin;type 2 diabetes mellitus;mortality;Taiwan | 公開日期: | 2012 | 卷: | 110 | 期: | 5 | 起(迄)頁: | 668-673 | 來源出版物: | BJU Int. | 摘要: | OBJECTIVE To evaluate whether insulin use in diabetic patients could be predictive for prostate cancer mortality. PATIENTS AND METHODS A total of 39 135 diabetic men aged >= 40 years from a nationally representative cohort were followed prospectively from 1995 to 2006 for prostate cancer mortality. Cox proportional hazards models were used to estimate the hazard ratios for the following independent variables: age, diabetes type, diabetes duration, body mass index, smoking, insulin use and area of residence. The models were created for patients aged >= 40 years and >= 65 years, separately; and before and after excluding patients with a duration between onset of diabetes and prostate cancer mortality <5 years. RESULTS A total of 105 diabetic men died of prostate cancer during follow-up. Age was the only significant risk factor. Insulin use was associated with an insignificantly higher risk of prostate cancer mortality ranging from 24% to 49%. When stratified by the duration of insulin use < 5 and >= 5 years, a lack of significant association was also observed. CONCLUSIONS Insulin use in diabetic patients does not significantly predict the mortality from prostate cancer. Further confirmation in other ethnicities is needed. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259019 |
顯示於: | 醫學系 |
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