DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院;臺大醫院-內科部;臺大醫院雲林分院;臺大醫學院; | en |
dc.contributor.author | Hsu, Chih-Neng | en_US |
dc.contributor.author | CHIA-HSUIN CHANG | en_US |
dc.contributor.author | Lin, Yu-Sheng | en_US |
dc.contributor.author | JOU-WEI LIN | en_US |
dc.contributor.author | Caffrey, James L | en_US |
dc.creator | Hsu, Chih-Neng;Chang, Chia-Hsuin;Lin, Yu-Sheng;Lin, Jou-Wei;Caffrey, James L. | en |
dc.creator | 張家勳 ;林昭維 ;許智能 | zh-tw |
dc.date | 2013 | en |
dc.date.accessioned | 2014-02-14T05:29:32Z | - |
dc.date.accessioned | 2018-07-11T06:48:24Z | - |
dc.date.available | 2014-02-14T05:29:32Z | - |
dc.date.available | 2018-07-11T06:48:24Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259078 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw/bitstream/246246/259078/1/index.html | - |
dc.description.abstract | Background: Known associations between diabetes and cancer could logically be attributed to hyperglycemia, hypersecretion of insulin, and/or insulin resistance. This study examined the relationship between initial glycemic biomarkers among men and women with impaired fasting glucose or undiagnosed diabetes and cancer mortality during follow up.
Methods: The cohort included subjects aged 40 years and above from the Third National Health and Nutrition Examination Survey (NHANES III) with fasted serum glucose >100 mg/dl without the aid of pharmaceutical intervention (insulin or oral hypoglycemics). Cancer mortality was obtained from the NHANES III-linked follow-up database (up to December 31, 2006). A Cox regression model was applied to test for the associations between cancer mortality and fasting serum glucose, insulin, glycosylated hemoglobin (HbA1c), C-peptide, insulin like growth factor (IGF-1), IGF binding protein 3 (IGFBP3) and estimated insulin resistance.
Results: A total of 158 and 100 cancer deaths were recorded respectively from 1,348 men and 1,161 women during the mean 134-month follow-up. After adjusting for the effect of age and smoking in women, all-cause cancer deaths (HR: 1.96 per pmol/ml, 95% CI: 1.02-3.77) and lung cancer deaths (HR: 2.65 per pmol/ml, 95% CI: 1.31-5.36) were specifically associated with serum C-peptide concentrations. Similar associations in men were not statistically significant. Serum glucose, HbA1c, IGF-1, IGFBP3 and HOMA were not independently related to long-term cancer mortality.
Conclusion: C-peptide analyses suggest a modest association with both all-cause and lung cancer mortality in women but not in men. Further studies will be required to explore the mechanisms. | en_US |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | PLoS One, 8(2) | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; C peptide; glucose; hemoglobin A1c; insulin; somatomedin binding protein 3; somatomedin C; adult; age; aged; article; cancer mortality; controlled study; diabetes mellitus; disease association; female; follow up; glucose blood level; hemoglobin blood level; human; impaired glucose tolerance; insulin blood level; insulin release; insulin resistance; lung cancer; major clinical study; male; protein blood level; risk assessment; sex difference; smoking; Adult; Aged; Biological Markers; C-Peptide; Cohort Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Prediabetic State; Prognosis; Risk Factors; Smoking; Survival Rate | - |
dc.title | Association of Serum C-Peptide Concentrations with Cancer Mortality Risk in Pre-Diabetes or Undiagnosed Diabetes | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1371/journal.pone.0055625 | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
dc.relation.pages | e55625 | en_US |
dc.relation.journalvolume | 8 | en_US |
dc.relation.journalissue | 2 | en_US |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259078/1/index.html | - |
item.fulltext | with fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.orcid | 0000-0003-0024-6177 | - |
crisitem.author.orcid | 0000-0001-7614-3903 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系
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