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  1. NTU Scholars
  2. 醫學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/190265
Title: EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
Authors: Yang, Shi-Yi
Yang, Tsung-Ying
Li, Yao-Jen
Chen, Kun-Chieh
Liao, Kuo-Meng
Hsu, Kuo-Hsuan
Tsai, Chi-Ren
Chen, Chih-Yi
Hsu, Chung-Ping
Hsia, Jiun-Yi
Chuang, Cheng-Yen
Tsai, Ying-Huang
Chen, Kuan-Yu
Huang, Ming-Shyan
Su, Wu-Chou
Chen, Yuh-Min
Hsiung, Chao A.
Shen, Chen-Yang
Chang, Gee-Chen
Yang, Pan-Chyr
Chen, Chien-Jen
Keywords: EGFR mutation;polymorphisms;DNA repair and detoxification-related metabolism;never-smokers;lung adenocarcinoma
Issue Date: 2013
Journal Volume: 132
Journal Issue: 2
Start page/Pages: 449-458
Source: Int. J. Cancer 
Abstract: 
We explored potential associations between genetic polymorphisms in genes related to DNA repair and detoxification metabolism and epidermal growth factor receptor (EGFR) mutations in a cohort of 410 never-smoking patients with lung adenocarcinoma. Multivariate-adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CI) of EGFR mutation status in association with the genotypes of DNA repair and detoxification metabolism genes were evaluated using logistic regression analysis. We found an association between in-frame deletion in EGFR exon 19 and a single nucleotide polymorphism (SNP) rs1800566C/T located in NQO1 (aOR, 2.2 with 95% CI, 1.04.8) in female never-smokers. The SNP rs744154C/G in ERCC4 was also associated with the EGFR exon 19 in-frame deletion both in never-smokers (aOR, 1.7 with 95% CI, 1.03.0) and female never-smokers (aOR, 1.9 with 95% CI, 1.03.6). Although the association was marginally significant in multivariate logistic regression analysis, the A/A genotype of rs1047840 in EXO1 was associated with a 7.6-fold increase in the occurrence of the EGFR exon 19 in-frame deletion in female never-smokers. Moreover, risk alleles in NQO1, ERCC4 and EXO1 were associated with an increasing aOR of the EGFR exon 19 in-frame deletion both in never-smokers (p = 0.007 for trend) and female never-smokers (p = 0.002 for trend). Our findings suggest that the in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients, especially in females.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/259147
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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