DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院;臺大醫院-內科部;臺大醫院-急診醫學部;臺大醫院雲林分院; | en |
dc.contributor.author | Chang, Shy-Shin | en |
dc.contributor.author | Hsieh, Wen-Han | en |
dc.contributor.author | Liu, Ting-Shou | en |
dc.contributor.author | Lee, Si-Huei | en |
dc.contributor.author | Wang, Chih-Hung | en |
dc.contributor.author | Chou, Hao-Chang | en |
dc.contributor.author | Yeo, Yee Hui | en |
dc.contributor.author | Tseng, Ching-Ping | en |
dc.contributor.author | Lee, Chien-Chang | en |
dc.creator | Chang, Shy-Shin;Hsieh, Wen-Han;Liu, Ting-Shou;Lee, Si-Huei;Wang, Chih-Hung;Chou, Hao-Chang;Yeo, Yee Hui;Tseng, Ching-Ping;Lee, Chien-Chang | en |
dc.creator | 李建璋 | zh-tw |
dc.date | 2013 | en |
dc.date.accessioned | 2014-02-14T07:20:54Z | - |
dc.date.accessioned | 2018-07-11T07:04:43Z | - |
dc.date.available | 2014-02-14T07:20:54Z | - |
dc.date.available | 2018-07-11T07:04:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259404 | - |
dc.description.abstract | Background: Blood culture is viewed as the golden standard for the diagnosis of sepsis but suffers from low sensitivity and long turnaround time. LightCycler SeptiFast (LC-SF) is a real-time multiplex polymerase chain reaction test able to detect 25 common pathogens responsible for bloodstream infections within hours. We aim to assess the accuracy of LC-SF by systematically reviewing the published studies.
Method: Related literature on Medline, Embase, and Cochrane databases was searched up to October 2012 for studies utilizing LC-SF to diagnose suspected sepsis and that provided sufficient data to construct two-by-two tables.
Results: A total of 34 studies enrolling 6012 patients of suspected sepsis were included. The overall sensitivity and specificity for LC-SF to detect bacteremia or fungemia was 0.75 (95% CI: 0.65-0.83) and 0.92 (95% CI: 0.90-0.95), respectively. LC-SF had a high positive likelihood ratio (10.10) and a moderate negative likelihood ratio (0.27). Specifically, LC-SF had a sensitivity of 0.80 (95% CI: 0.70-0.88) and a specificity of 0.95(95% CI: 0.93-0.97) for the bacteremia outcome, and a sensitivity of 0.61 (95% CI: 0.48-0.72) and a specificity of 0.99 (95% CI: 0.99-0.99) for the fungemia outcome. High heterogeneity was found in the bacteremia outcome subgroup but not in the fungemia outcome subgroup.
Conclusion: LC-SF is of high rule-in value for early detection of septic patients. In a population with low pretest probability, LC-SF test can still provide valuable information for ruling out bacteremia or fungemia. | en |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | PLoS One, 8(5) | en |
dc.relation.ispartof | PLoS One | - |
dc.title | Multiplex PCR System for Rapid Detection of Pathogens in Patients with Presumed Sepsis - A Systemic Review and Meta-Analysis | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 5 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259404/1/index.html | - |
item.grantfulltext | open | - |
item.fulltext | with fulltext | - |
顯示於: | 醫學系
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