https://scholars.lib.ntu.edu.tw/handle/123456789/190597
標題: | Clinical applicability of quantitative nailfold capillaroscopy in differential diagnosis of connective tissue diseases with Raynaud's phenomenon | 作者: | Wu P.-C. Huang M.-N. YU-MIN KUO SONG-CHOU HSIEH CHIA-LI YU |
關鍵字: | connective tissue diseases;diagnosis;nailfold capillaroscopy;Raynaud's phenomenon | 公開日期: | 2013 | 起(迄)頁: | 482-488 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Nailfold capillaroscopy is a useful tool to distinguish primary from secondary Raynaud's phenomenon (RP) by examining the morphology of nailfold capillaries but its role in disease diagnosis is not clearly established. The purpose of this study was to evaluate the roles of quantitative nailfold capillaroscopy in differential diagnosis of connective tissue diseases (CTDs) with RP. Methods: The data between the year 2005 and 2009 were retrieved from the nailfold capillaroscopic database of National Taiwan University Hospital (NTUH). Only the data from the patients with RP were analyzed. The criteria for interpretation of capillaroscopic findings were predefined. The final diagnoses of the patients were based on the American College of Rheumatology classification criteria for individual diseases, independent of nailfold capillaroscopic findings. The sensitivity and the specificity of each capillaroscopic pattern to the diseases were determined. Results: The data from a total of 67 patients were qualified for the current study. We found the sensitivity and specificity of scleroderma pattern for systemic sclerosis (SSc) were 89.47% and 80%, and the specificity of the early, active, and late scleroderma patterns for SSc reached 87.5%, 97.5%, and 95%, respectively. The sensitivity/specificity of systemic lupus erythematosus (SLE) pattern for SLE and polymyositis/dermatomyositis (PM/DM) pattern for PM/DM were 33.33%/95.45% and 60%/96.3%, respectively. The sensitivity/specificity of mixed connective tissue disease (MCTD) pattern for MCTD were 20%/100%. Conclusion: The nailfold capillaroscopic (NC) patterns may be useful in the differential diagnosis of CTDs with RP. The NC patterns for SSc and PM/DM are both sensitive and specific to the diseases, while the SLE and MCTD patterns exhibit high specificity but relatively low sensitivity. Copyright (C) 2012, Elsevier Taiwan LLC Et Formosan Medical Association. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259482 | DOI: | 10.1016/j.jfma.2012.02.029 | SDG/關鍵字: | adult; aged; article; capillaroscopy; connective tissue disease; controlled study; dermatomyositis; diagnostic test accuracy study; differential diagnosis; female; human; major clinical study; male; nailfold capillaroscopy; polymyositis; Raynaud phenomenon; scleroderma; sensitivity and specificity; systemic lupus erythematosus; systemic sclerosis; connective tissue diseases; diagnosis; nailfold capillaroscopy; Raynaud's phenomenon; Adult; Aged; Connective Tissue Diseases; Diagnosis, Differential; Female; Humans; Male; Microscopic Angioscopy; Middle Aged; Raynaud Disease; Sensitivity and Specificity |
顯示於: | 醫學系 |
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