Pneumonia Risk and Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
Resource
J. Epidemiol., 23(5), 344-350
Journal
Journal of Epidemiology
Pages
344-350
Date Issued
2013
Date
2013
Author(s)
Abstract
Background: Recent studies have shown that use of angiotensin-converting enzyme (ACE) inhibitors may decrease pneumonia risk in various populations. We investigated the effect of ACE inhibitors and angiotensin II receptor blockers (ARBs) on pneumonia hospitalization in the general population of Taiwan.
Methods: We conducted a case-crossover study using the Taiwan Longitudinal Health Insurance Database for the year 2005. Data from patients hospitalized for the first time for pneumonia during 1997-2007 were analyzed. The case period was defined as the 30 days before admission; the periods 90 to 120 days and 180 to 210 days before admission were used as control periods. Prescribing status of ACE inhibitors and ARBs during the 3 periods was assessed for each patient. Conditional logistic regression was used to estimate the odds ratio (OR) for pneumonia associated with use of ACE inhibitors and ARBs.
Results: We identified 10 990 cases of hospitalization for new pneumonia. After adjustment for time-variant confounding factors, pneumonia was not associated with use of ACEI or ARBS: the ORs were 0.99 (95% CI, 0.81-1.21) and 0.96 (0.72-1.28), respectively. No association was seen for cumulative defined daily doses (DDDs), as compared with nonusers, for 0 to 30, 31 to 60, or more than 60 DDDs. The results were found to be robust in sensitivity analysis.
Conclusions: Neither the use nor cumulative dose of ACE inhibitors or ARBs was associated with pneumonia among the Taiwanese general population.
Subjects
angiotensin-converting enzyme inhibitor
angiotensin II receptor blockers
pneumonia
case-crossover study
SDGs
Other Subjects
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; adult; aged; article; case control study; chemically induced disorder; crossover procedure; factual database; female; hospitalization; human; male; middle aged; pneumonia; risk; statistics; Taiwan; treatment outcome; Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Case-Control Studies; Cross-Over Studies; Databases, Factual; Female; Hospitalization; Humans; Male; Middle Aged; Pneumonia; Risk; Taiwan; Treatment Outcome
File(s)![Thumbnail Image]()
Loading...
Name
index.html
Size
23.16 KB
Format
HTML
Checksum
(MD5):d673a1a6e798389864c399204c2dff9e