Next-Generation Sequencing in the Genetics of Human Atrial Fibrillation
Resource
Acta Cardiol. Sin., 29(4), 317-322
Journal
Acta Cardiol. Sin.
Journal Volume
29
Journal Issue
4
Pages
317-322
Date Issued
2013
Date
2013
Author(s)
Hsieh, Chia-Shan
Chuang, Eric Y.
Juang, Jyh-Ming Jimmy
Hwang, Juey-Jen
Tseng, Chuen-Den
Chiang, Fu-Tien
Lai, Ling-Ping
Lin, Jiunn-Lee
Tsai, Chia-Ti
Abstract
International Human Genome Sequencing Consortium published the first draft of the human genome in the journal Nature in February 2001, providing the sequence of the entire genome's three billion base pairs. The Human Genome Project involves a concerted effort to better understand the human DNA sequence through identification of all the genes. The knowledge that can be derived from the genome could result in the development of novel diagnostic assays, targeted therapies and the improved ability to predict the onset, severity and progression of diseases. This has been made possible by many parallelized, high-throughput technologies such as next-generation sequencing. In this review, we discuss the possible application of next-generation sequencing in finding the susceptibility gene(s) or disease mechanism of an important human arrhythmia called atrial fibrillation.
Subjects
Arrhythmia
Atrial fibrillation
Genetics
Next-generation sequencing
SDGs
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