DC 欄位 | 值 | 語言 |
dc.contributor | 臺大公衛學院-流行病學與預防醫學研究所;臺大醫院;臺大醫院-內科部;臺大醫院-皮膚部;臺大醫學院;臺大醫學院-臨床醫學研究所;臺大醫學院-護理學系暨研究所; | en |
dc.contributor.author | Ko, Mei-Ju | en |
dc.contributor.author | Wu, Hon-Yen | en |
dc.contributor.author | Chen, Hung-Yuan | en |
dc.contributor.author | Chiu, Yen-Ling | en |
dc.contributor.author | Hsu, Shih-Ping | en |
dc.contributor.author | Pai, Mei-Fen | en |
dc.contributor.author | Ju-YehYang | en |
dc.contributor.author | Lai, Chun-Fu | en |
dc.contributor.author | Lu, Hui-Min | en |
dc.contributor.author | Huang, Shu-Chen | en |
dc.contributor.author | Yang, Shao-Yu | en |
dc.contributor.author | Wen, Su-Yin | en |
dc.contributor.author | Chiu, Hsien-Ching | en |
dc.contributor.author | Hu, Fu-Chang | en |
dc.contributor.author | Peng, Yu-Sen | en |
dc.contributor.author | Jee, Shiou-Hwa | en |
dc.creator | Ko, Mei-Ju;Wu, Hon-Yen;Chen, Hung-Yuan;Chiu, Yen-Ling;Hsu, Shih-Ping;Pai, Mei-Fen;Ju-YehYang ;Lai, Chun-Fu;Lu, Hui-Min;Huang, Shu-Chen;Yang, Shao-Yu;Wen, Su-Yin;Chiu, Hsien-Ching;Hu, Fu-Chang;Peng, Yu-Sen;Jee, Shiou-Hwa | en |
dc.creator | 紀秀華 ;賴俊夫 ;楊紹佑 ;邱顯清 | zh-tw |
dc.date | 2013 | en |
dc.date.accessioned | 2014-02-14T08:02:13Z | - |
dc.date.accessioned | 2018-07-11T07:06:16Z | - |
dc.date.available | 2014-02-14T08:02:13Z | - |
dc.date.available | 2018-07-11T07:06:16Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259521 | - |
dc.description.abstract | Background: Uremic pruritus is a common and intractable symptom in patients on chronic hemodialysis, but factors associated with the severity of pruritus remain unclear. This study aimed to explore the associations of metabolic factors and dialysis adequacy with the aggravation of pruritus.
Methods: We conducted a 5-year prospective cohort study on patients with maintenance hemodialysis. A visual analogue scale (VAS) was used to assess the intensity of pruritus. Patient demographic and clinical characteristics, laboratory parameters, dialysis adequacy (assessed by Kt/V), and pruritus intensity were recorded at baseline and follow-up. Change score analysis of the difference score of VAS between baseline and follow-up was performed using multiple linear regression models. The optimal threshold of Kt/V, which is associated with the aggravation of uremic pruritus, was determined by generalized additive models and receiver operating characteristic analysis.
Results: A total of 111 patients completed the study. Linear regression analysis showed that lower Kt/V and use of low-flux dialyzer were significantly associated with the aggravation of pruritus after adjusting for the baseline pruritus intensity and a variety of confounding factors. The optimal threshold value of Kt/V for pruritus was 1.5 suggested by both generalized additive models and receiver operating characteristic analysis.
Conclusions: Hemodialysis with the target of Kt/V >1.5 and use of high-flux dialyzer may reduce the intensity of pruritus in patients on chronic hemodialysis. Further clinical trials are required to determine the optimal dialysis dose and regimen for uremic pruritus. | en |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | PLoS One, 8(8) | en |
dc.relation.ispartof | PLoS One | - |
dc.title | Uremic Pruritus, Dialysis Adequacy, and Metabolic Profiles in Hemodialysis Patients: A Prospective 5-Year Cohort Study | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 8 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259521/1/index.html | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 醫學系
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