DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院-內科部;臺大醫院-外科部; | en |
dc.contributor.author | Wu, Vin-Cent | en |
dc.contributor.author | Wu, Cho-Kai | en |
dc.contributor.author | Chang, Yi-Cheng | en |
dc.contributor.author | Young, Guang-Huar | en |
dc.contributor.author | Chen, Shann-Ching | en |
dc.contributor.author | Yang, Wei-Shiung | en |
dc.contributor.author | Chen, Chien-Yuan | en |
dc.contributor.author | Wang, Wei-Jie | en |
dc.contributor.author | Lin, Chien-Yu | en |
dc.contributor.author | Lin, Yen-Hung | en |
dc.contributor.author | Lin, Shuei-Liong | en |
dc.contributor.author | Chueh, Shih-Chieh | en |
dc.contributor.author | Wu, Kwan-Dun | en |
dc.creator | Wu, Vin-Cent;Wu, Cho-Kai;Chang, Yi-Cheng;Young, Guang-Huar;Chen, Shann-Ching;Yang, Wei-Shiung;Chen, Chien-Yuan;Wang, Wei-Jie;Lin, Chien-Yu;Lin, Yen-Hung;Lin, Shuei-Liong;Chueh, Shih-Chieh;Wu, Kwan-Dun | en |
dc.creator | 陳建源 ;楊偉勛 ;吳卓鍇 ;吳允升 ;吳寬墩 ;林水龍 ;林彥宏 | zh-tw |
dc.date | 2013 | en |
dc.date.accessioned | 2014-02-14T08:08:15Z | - |
dc.date.accessioned | 2018-07-11T07:06:22Z | - |
dc.date.available | 2014-02-14T08:08:15Z | - |
dc.date.available | 2018-07-11T07:06:22Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259538 | - |
dc.description.abstract | Objective:In mice, a lack of cryptochrome results in up-regulation of aldosterone production due to high expression of the 3-hydroxysteroid dehydrogenases (HSD3) gene. The HSD3 pathway might play a pivotal role in aldosterone synthesis. This study aimed to determine the association of HSD3 and HSD32 gene variations with primary aldosteronism in a Taiwanese population.Method:In this case-control cohort, 688 consecutive ethnically matched unrelated individuals including 362 primary aldosteronism and 326 essential hypertension cases were recruited. Nineteen tag single-nucleotide polymorphisms (SNPs) across HSD31, HSD32, and CYP112 were genotyped. Expression of HSD3 mRNA and immunohistochemical stain of HSD3 in the specimens of aldosterone-producing adenoma (APA) was compared with that in nonfunctional incidentaloma.Results:The SNPs of rs12410453 A allele in HSD32 gene [odds ratio (OR) 1.92, 95% confidence interval (CI) 1.13-3.32, P=0.018] and rs6203 C allele in the HSD31 gene (OR 2.21, 95% CI 1.28-3.95, P=0.006) showed significant association with primary aldosteronism, with corresponding population attributable risk of 6.7 and 30.7%, respectively. Primary aldosteronism patients of non-CC in rs6203 and non-GA in rs12401453 had lower plasma aldosterone-to-renin ratio. A haplotype in a linkage disequilibrium block containing rs6203 associated significantly with serum potassium level (OR 1.24, 95% CI 1.02-1.24, P=0.026). The expressions of HSD31 mRNA, HSD32 mRNA and HSD3 protein were increased in APA, as compared to incidentaloma.Conclusion:Risk-conferring genetic variations in the HSD3 gene influenced susceptibility of primary aldosteronism. Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin ratio. | en |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | J. Hypertens., 31(7), 1396-1405 | en |
dc.relation.ispartof | J. Hypertens. | - |
dc.subject | haplotype | en |
dc.subject | HSD3 beta | en |
dc.subject | immunohistochemistry | en |
dc.subject | primary aldosteronism | en |
dc.subject | TagSNP | en |
dc.title | Association of the variations in the HSD3 beta gene with primary aldosteronism | en |
dc.relation.pages | 1396-1405 | - |
dc.relation.journalvolume | 31 | - |
dc.relation.journalissue | 7 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259538/1/index.html | - |
item.grantfulltext | open | - |
item.fulltext | with fulltext | - |
顯示於: | 醫學系
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