Statins reduce the incidence of dementia in patients with atrial fibrillation: a nationwide cohort study
Resource
Eur. Heart J., 34, 740-741
Journal
European Heart Journal
Pages
P4077
Date Issued
2013
Date
2013
Author(s)
Liao, M. -T.
Tsai, C. T.
Lin, J. L.
Abstract
Purpose: Atrial Fibrillation (AF) is associated with increased risk of dementia. AF has been documented to be a predisposing factor of dementia. The aim of this study was a prospective observational study to evaluate whether the usage of statins could reduce the incidence of dementia. Methods: A total of 5221 patients who had been diagnosed as having AF by using ambulatory and inpatient claim data and were above 20 years old were enrolled from January 1, 1997 to January 1, 2010. Patients who were under statins treatment were defined as group 1 (1652 patients). Patients without statins were defined as group 2 (3569 patients). Results: During a follow-up of 5.90±3.39 years, group 1 and 2 had 34 (2.1%) and 126 (3.5%) patients experiencing new-onset dementia. Group 1 had significant lower incidence of new-onset dementia than group 2 (P=0.002). The Kaplan-Meier curve demonstrated that patients with statins were associated with a lower rate of dementia during the follow-up period (P=0.004, Figure 1). Cox-regression analysis showed that the risk factors for new-onset dementia were gender (OR=0.642 for male vs female, P=0.006), statins use (OR=0.565, P=0.004) and CHADS2 score (OR=2.571, score 0 vs 1, P=0.032; OR=2.081, score 0 vs 2, P=0.099; OR=2.951, score 0 vs 3, P=0.015; OR=3.646, score 0 vs 4, P=0.004; OR=2.688, score 0 vs 5, P=0.055; OR=7.065, score 0 vs 6, P=0.003). The history of myocardial infarction, peripheral artery disease, coronary artery disease, chronic kidney disease and valvular heart disease were not associated with new-onset dementia. Figure 1 Conclusion: Statins might reduce the incidence of new-onset dementia in patients with atrial fibrillation.
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