https://scholars.lib.ntu.edu.tw/handle/123456789/190672
標題: | Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults | 作者: | Lin, Chien-Yu Lin, Lian-Yu Wen, Ting-Wen Lien, Guang-Wen Chien, Kuo-Liong Hsu, Sandy H. J. Liao, Chien-Chang Sung, Fung-Chang Chen, Pau-Chung Su, Ta-Chen |
關鍵字: | Perfluorinated chemicals;Perfluorooctane sulfate;Perfluorononanoic acid;Carotid intima-media thickness | 公開日期: | 2013 | 卷: | 168 | 期: | 4 | 起(迄)頁: | 3309-3316 | 來源出版物: | Int. J. Cardiol. | 摘要: | Background: Perfluorinated chemicals (PFCs) have been widely used for years in a variety of products worldwide. Although epidemiological findings have shown that PFC levels are positively associated with cholesterol and uric acid levels, it is unknown whether PFCs are associated with atherosclerosis. Methods: We recruited 664 subjects (12-30 years) from a population-based sample of adolescents and young adults based on a mass urine screening to determine the relationship between serum levels of PFCs and carotid intima-media thickness (CIMT). Results: The median concentrations and ranges of perfluorooctanoic acid (PFOA), perfluorooctane sulfate (PFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFUA) were 3.49 (0.75-52.2) ng/mL, 8.65 (0.11-85.90) ng/mL, 0.38 (0.38-25.4) ng/mL, and 6.59 (1.50-105.7) ng/mL, respectively. After controlling for age, gender, smoking status, systolic blood pressure, body mass index, low-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance, multiple linear regression analysis revealed that CIMT increased significantly across quartiles of PFOS (0.434 mm, 0.446 mm, 0.458 mm, 0.451 mm; P for trend <0.001). Subpopulation analysis showed the association between PFOS and CIMT was more evident and significant in females, non-smokers, subjects of age 12-19 years, BMI < 24, and those with APOE genotype of E2 carrier and E3/E3. Conclusions: Higher serumconcentrations of PFOS were associated with an increase of carotid IMT in this cohort of adolescents and young adults. Further studies are warranted to clarify the causal relationship between PFOS and atherosclerosis. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259575 |
顯示於: | 醫學系 |
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