https://scholars.lib.ntu.edu.tw/handle/123456789/190844
標題: | Colistin Resistance Mechanisms in Klebsiella pneumoniae Strains from Taiwan | 作者: | Cheng, Yi-Hsiang Lin, Tzu-Lung Pan, Yi-Jiun Wang, Yu-Ping Lin, Yi-Tsung JIN-TOWN WANG |
公開日期: | 2015 | 起(迄)頁: | 2909-2913 | 來源出版物: | Antimicrobial Agents and Chemotherapy | 摘要: | Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/270673 | DOI: | 10.1128/AAC.04763-14 |
顯示於: | 醫學系 |
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