https://scholars.lib.ntu.edu.tw/handle/123456789/190982
標題: | Can leflunomide play a role in cytomegalovirus disease prophylaxis besides its antirheumatic effects? | 作者: | CHENG-HSUN LU JIA-HUEI TSAI MU-ZON WU CHIA-LI YU SONG-CHOU HSIEH |
公開日期: | 2015 | 起(迄)頁: | 93-96 | 來源出版物: | Antiviral Therapy | 摘要: | Leflunomide, a disease-modifying antirheumatic drug (DMARD), has shown effectiveness in many autoimmune disorders and can suppress cytomegalovirus (CMV) disease in humans. Thus, it is possible for leflunomide to play a role in CMV prophylaxis or pre-emptive therapy in high-risk patients in addition to its application as a DMARD for autoimmune disorders. We describe two adult patients who developed CMV disease after administration of low-dose leflunomide. One patient was successfully treated with an increasing leflunomide dosage, resulting in a long-term suppression of serum CMV viral load. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/278661 | DOI: | 10.3851/IMP2796 | SDG/關鍵字: | corticosteroid; ganciclovir; immunoglobulin G; leflunomide; prednisolone; rituximab; antirheumatic agent; antivirus agent; isoxazole derivative; leflunomide; abdominal pain; adult; aged; Article; case report; colitis; colonoscopy; Cytomegalovirus; cytomegalovirus infection; dose response; drug dose increase; drug dose reduction; drug megadose; female; histopathology; human; human tissue; hyperlipidemia; immunoglobulin blood level; immunohistochemistry; infection prevention; inflammatory bowel disease; kidney failure; low drug dose; lupus erythematosus nephritis; nephrotic syndrome; priority journal; rectum hemorrhage; systemic lupus erythematosus; virus load; virus pneumonia; Cytomegalovirus Infections; dose calculation; drug administration; drug effects; physiology; virology; Adult; Aged; Antirheumatic Agents; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Drug Administration Schedule; Drug Dosage Calculations; Female; Humans; Isoxazoles; Viral Load |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。