https://scholars.lib.ntu.edu.tw/handle/123456789/191004
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 臺大醫院-內科部;臺大醫院-病理部;臺大醫院-檢驗醫學部;臺大醫學院;臺大醫學院-腫瘤醫學研究所; | - |
dc.contributor.author | HSIN-AN HOU | en_US |
dc.contributor.author | Liu, Chieh-Yu | en_US |
dc.contributor.author | Kuo, Yuan-Yeh | en_US |
dc.contributor.author | WEN-CHIEN CHOU | en_US |
dc.contributor.author | CHENG-HONG TSAI | en_US |
dc.contributor.author | CHIEN-CHIN LIN | en_US |
dc.contributor.author | LIANG-IN LIN | en_US |
dc.contributor.author | Tseng, Mei-Hsuan | en_US |
dc.contributor.author | Chiang, Ying-Chieh | en_US |
dc.contributor.author | Liu, Ming-Chih | en_US |
dc.contributor.author | Liu, Chia-Wen | en_US |
dc.contributor.author | JIH-LUH TANG | en_US |
dc.contributor.author | MING YAO | en_US |
dc.contributor.author | Li, Chi-Cheng | en_US |
dc.contributor.author | SHANG-YI HUANG | en_US |
dc.contributor.author | BOR-SHENG KO | en_US |
dc.contributor.author | SZU-CHUN HSU | en_US |
dc.contributor.author | Chen, Chien-Yuan | en_US |
dc.contributor.author | Lin, Chien-Ting | en_US |
dc.contributor.author | SHANG-JU WU | en_US |
dc.contributor.author | WOEI TSAY | en_US |
dc.contributor.author | HWEI-FANG TIEN | en_US |
dc.creator | Hou, Hsin-An;Liu, Chieh-Yu;Kuo, Yuan-Yeh;Chou, Wen-Chien;Tsai, Cheng-Hong;Lin, Chien-Chin;Lin, Liang-In;Tseng, Mei-Hsuan;Chiang, Ying-Chieh;Liu, Ming-Chih;Liu, Chia-Wen;Tang, Jih-Luh;Yao, Ming;Li, Chi-Cheng;Huang, Shang-Yi;Ko, Bor-Sheng;Hsu, Szu-Chun;Chen, Chien-Yuan;Lin, Chien-Ting;Wu, Shang-Ju;Tsay, Woei;Tien, Hwei-Fang | en |
dc.creator | 林建嶔;林吉崇;蔡偉;姚明;陳建源;柯博升;徐思淳;田蕙芬;劉敏枝;郭遠燁;黃聖懿;吳尚儒;唐季祿;周文堅;侯信安 | zh-tw |
dc.date | 2016 | - |
dc.date.accessioned | 2017-04-25T10:23:40Z | - |
dc.date.accessioned | 2018-07-11T07:10:48Z | - |
dc.date.available | 2017-04-25T10:23:40Z | - |
dc.date.available | 2018-07-11T07:10:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/278739 | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-84961589389&doi=10.18632%2foncotarget.7000&origin=inward&txGid=21b80847bb0069e3ce8014408892882e | - |
dc.description.abstract | Mutations in splicing factor (SF) genes are frequently detected in myelodysplastic syndrome, but the prognostic relevance of these genes mutations in acute myeloid leukemia (AML) remains unclear. In this study, we investigated mutations of three SF genes, SF3B1, U2AF1 and SRSF2, by Sanger sequencing in 500 patients with de novo AML and analysed their clinical relevance. SF mutations were identified in 10.8% of total cohort and 13.2% of those with intermediate-risk cytogenetics. SF mutations were closely associated with RUNX1, ASXL1, IDH2 and TET2 mutations. SF-mutated AML patients had a significantly lower complete remission rate and shorter disease-free survival (DFS) and overall survival (OS) than those without the mutation. Multivariate analysis demonstrated that SF mutation was an independent poor prognostic factor for DFS and OS. A scoring system incorporating SF mutation and ten other prognostic factors was proved very useful to risk-stratify AML patients. Sequential study of paired samples showed that SF mutations were stable during AML evolution. In conclusion, SF mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression. These mutations may be potential targets for novel treatment and biomarkers for disease monitoring in AML. | en_US |
dc.language | en-us | - |
dc.publisher | Impact Journals LLC | en_US |
dc.relation | Oncotarget, 7(8), 9084-9101 | en_US |
dc.relation.ispartof | Oncotarget | en_US |
dc.subject | de novo AML | en_US |
dc.subject | splicing factor mutations | en_US |
dc.subject | prognosis | en_US |
dc.subject | paired sample | en_US |
dc.title | Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.18632/oncotarget.7000 | - |
dc.identifier.pmid | 26812887 | - |
dc.relation.pages | 9084 | en_US |
dc.relation.journalvolume | 7 | en_US |
dc.relation.journalissue | 8 | en_US |
dc.relation.pageend | 9101 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2780-4845 | - |
crisitem.author.orcid | 0000-0003-2967-698X | - |
crisitem.author.orcid | 0000-0002-4174-8766 | - |
crisitem.author.orcid | 0000-0001-7160-2285 | - |
crisitem.author.orcid | 0000-0002-3561-1093 | - |
crisitem.author.orcid | 0000-0003-4021-3281 | - |
crisitem.author.orcid | 0000-0003-2932-0019 | - |
crisitem.author.orcid | 0000-0001-5688-3410 | - |
crisitem.author.orcid | 0000-0002-7965-7579 | - |
crisitem.author.orcid | 0000-0003-2831-8822 | - |
crisitem.author.orcid | 0000-0002-0772-869X | - |
crisitem.author.orcid | 0000-0001-6244-3868 | - |
crisitem.author.orcid | 0000-0002-1384-5593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。